Hostname: page-component-745bb68f8f-g4j75 Total loading time: 0 Render date: 2025-01-24T05:47:55.420Z Has data issue: false hasContentIssue false
  • English
  • Français

Plasmodium brasilianum in the common marmoset Callithrix jacchus

Published online by Cambridge University Press:  06 April 2009

Nina Wedderburn ,
G. H. Mitchell  and
D. R. Davies
Nina Wedderburn
Affiliation:
Department of Pathology, Royal College of Surgeons of England, Lincoln's Inn Fields, London WC2A 3PN
G. H. Mitchell
Affiliation:
Department of Chemical Pathology, Guy's Hospital Medical School, St Thomas's Street, London SE1 9RT
D. R. Davies
Affiliation:
Department of Histopathology, St Thomas's Hospital, Lambeth Palace Road, London SE1 7EH
Get access Rights & Permissions [Opens in a new window]

Extract

Chronic quartan malarial infection has been established in the common marmoset (Callithrix jacchius). Plasniodium brasilianunm from a douroucouli monkey (Aotus trivirgatus) was used to infect splenectomized twin animals, passed to an intact animal, and then to 4 other intact adults, 2 pairs of twins. In 2 of the 4 latter animals there was continuing patency with parasitaemias of ≤0·5% parasitized erythrocytes for 30 weeks. The other 2 had lower initial levels of paraaitaemia; in 1 of these parasitaemias remained low or subpatent. All marmosets developed lymphocytosis. One animal became ill 30 weeks after infection with anaemia, weight loss and mild proteinurea, the other 3 remained well. Histological examination showed minor changes in the kidneys; spleens of infected animals showed marked follicular hyperplasia and phagocytosis of pigment. The livers showed sinusoidal hyper cellularity and pigment deposition and in splenectomized animals, a marked lymphoid follicular hyperplasia in the portal tracts.

Type
Research Article
Information
Parasitology , Volume 90 , Issue 3 , June 1985 , pp. 573 - 578
Copyright
Copyright © Cambridge University Press 1985

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Barton, R. W., Thrall, R. S. & Neubauer, R. H. (1984). Binding of human lymphocyte specific monoclonal antibodies to common marmoset lymphoid cells. Cellular Immunology 84, 446–52.CrossRefGoogle ScholarPubMed
Brack, M. & Rothe, H. (1980). Fütterungsbedingte (Wasting disease) bei Weissbüscheläffchen (Callithrix jacchus). In Erkrankungen der Zootiere (ed. Ippen, R. and Schroder, H. D.), pp. 181–185. Berlin: Akademie-Verlag.Google Scholar
Contacos, P. G., Lunn, J. S., Coatney, G. R., Kilpatrick, J. W. & Jones, F. E. (1963). Quartan type malaria parasite of new world monkeys transmissible to man. Science 142, 676.CrossRefGoogle ScholarPubMed
Dalldorf, G., Linsell, C. A., Barnhart, F. E. & Martyn, R. (1964). An epidemiological approach to the lymphomas of African children and Burkitt's sarcoma of the jaws. Perspectives in Biology and Medicine 7, 435–49.CrossRefGoogle Scholar
Deane, L. M., Ferreira Neto, J. A., Okumura, M. & Ferreira, M. O. (1969). Malaria parasites of Brazilian monkeys. Revista do instituto de Medicina Tropical de Saĉo Paulo 11, 71–86.Google ScholarPubMed
Deane, L. M., Okumura, M. & Silveira, I. P. S. (1966). Infeccaĉo experimental do sagüi Callithrix jacchus pelo Plasinodium brasilianium. Revista Paulista de Medicina 68, 119.Google Scholar
DeThé, G., Dubouch, P., Fontaine, C., Wedderburn, N., Carter, R. L., Edwards, M. B. & Cohen, B. (1980). Natural antibodies to EBV–VCA antigens in common marmosets (Callithrix jacchus) and response after EBV inoculation. Intervirology 14, 284–91.Google ScholarPubMed
Dockrell, H. M., DeSouza, J. B. & Playfair, J. H. L. (1980). The role of the liver in immunity to blood-stage murine malaria. Immunology 41, 421–30.Google ScholarPubMed
Felton, S. C., Hoffmann, C. C., Kreier, J. P. & Glaser, H. (1984). Hematologic and immunologic responses in common marmosets (Callithrix jacchus) infected with Plasmodium knowlesi and Epstein-Barr virus. Laboratory Animal Science 34, 164–8.Google ScholarPubMed
Gengozian, N. (1969). Marmosets: their potential in experimental medicine. Annals of the New York Academy of Sciences 162, 336–62.CrossRefGoogle ScholarPubMed
Gonder, R. & Berenberg-Gossler, H. V. Von, (1908). Untersuchungen über Malaria-Plasmodien der Affen. Malaria Leipzig 1, 47–56.Google Scholar
Hutt, M. S. R. & Voller, A. (1976). Malarial infections in Aotus trivirgatus with special reference to liver pathology. Journal of Tropical Medicine and Hygiene 79, 106–10.Google ScholarPubMed
Hutt, M. S. H., Davies, D. R. & Voller, A. (1975). Malarial infections in Aotus trivirgatus with special reference to renal pathology. British Journal of Experimental Pathology 56, 429–38.Google ScholarPubMed
Langhorne, J. & Cohen, S. (1979). Plasmodium knowlesi in the marmoset (Callithrix jacchus). Parasitology 78, 67–76.CrossRefGoogle ScholarPubMed
Perrin, L. H., Mackey, L. J. & Miescher, P. A. (1982). The haematology of malaria in man. Seminars in Haematology 19, 70–82.Google ScholarPubMed
Porter, J. A., Johnson, C. M. & DeSousa, L. (1966). Prevalence of malaria in Panamanian primates. Journal of Parasitology 52, 669–70.CrossRefGoogle ScholarPubMed
Reiley, C. G. & Barrett, O. (1971). Leucocyte responses in acute malaria. American Journal of the Medical Sciences 262, 153–8.CrossRefGoogle ScholarPubMed
Taliaferro, W. H. & Cannon, P. H. (1936). The cellular reactions during primary infections and superinfections of Plasmodium brasilianum in Panamanian monkeys. Journal of Infectious Diseases 59, 72–125.CrossRefGoogle Scholar
Taliaferro, W. H. & Klüver, C. (1940 a). The haematology of malaria (Plasmodium brasilianum) in Panamanian monkeys. I. Numerical changes in leucocytes. Journal of Infectious Diseases 67, 121–61.CrossRefGoogle Scholar
Taliaferro, W. H. & Klüver, C. (1940 b). The haematology of malaria (Plasmodium brasilianum) in Panamanian monkeys. II. Morphology of leucocytes and origin of monocytes and macrophages. Journal of Infectious Diseases 67, 162–76.CrossRefGoogle Scholar
Taliaferro, W. H. & Taliaferro, L. G. (1934). Morphology, periodicity and course of infection of Plasmodium brasilianum in Panamanian monkeys. American Journal of Hygiene 20, 1–49.Google Scholar
Voller, A., Davies, D. R. & Hutt, M. S. H. (1973). Quartan malarial infections in Aotus trivirgatus with special reference to renal pathology. British Journal of Experimental Pathology 54, 457–68.Google ScholarPubMed
Wedderburn, N., Edwards, J. M. B., Desgranges, C., Fontaine, C., Cohen, B. & De Thé, G. (1984). Infectious mononucleosis-like response in common marmosets infected with Epstein-Barr virus. Journal of Infectious Diseases 150, 878–82.CrossRefGoogle ScholarPubMed
Wellde, B. T., Johnson, A. J., Williams, J. S. & Sadun, E. H. (1972). Experimental infection with Plasmodium faciparum in Aotus monkeys. American Journal of Tropical Medicine and Hygiene 21, 260–71.CrossRefGoogle Scholar
Wolfe, L. G. & Deinhardt, T. (1978). Overview of viral oncology studies in Saguinus and Callithrix species. Primate Medicine 10, 96–118.Google ScholarPubMed