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The Occurrence of Peculiar Bodies in Blood Cells of Animals after Treatment with some Chemical Compounds
Published online by Cambridge University Press: 06 April 2009
Extract
Oral and subcutaneous administration of the compounds aminopropyl-aminostyrylmethoxyquinoline trihydrochloride and o-β-diethylaminoethyl harmol hydrochloride causes the appearance of peculiar bodies in the blood cells of canaries and mice.
The bodies are irregular in shape and size, stain intensely blue with Leish-man's and Giemsa's stains, and are most numerous in erythrocytes, but occur also in eosinophiles, leucocytes and reticulo-endothelial cells.
The bodies show no cytological structure, are not seen to undergo multiplication, and are not transmissible by blood inoculation.
They are apparently non-living inclusions in the blood cells caused by the action of these two chemical compounds.
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