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Observations on the early migration of the larvae of Ascaris suum Goeze, 1782 in white mice

Published online by Cambridge University Press:  06 April 2009

D. Conwil Jenkins
Affiliation:
Department of Zoology, University College, Cardiff

Extract

The early (0–18 h) migration of the larva of Ascaris suum in the white mouse was studied.

The eggs hatched in all gut regions posterior to the stomach, the time of maximal release being between 4 and 8 h after infection. The caecum was the site of maximum larval penetration.

Penetrating second-stage larvae produced demonstrable spreading factor reaction with Evan's Blue in the mucosa of the gut. Larvae were located in the venules and lymphatics of the caecum wall as well as in the ileo-colic and hepatic portal veins. Larvae were found in the liver after 9 h and in the lungs 12 h after infection. Larvae were not seen in the muscula externa of the gut and eggs were not found in any region of the body other than the gut lumen.

A similar pattern of larval distribution was seen in the gut wall of the rat and the guinea-pig.

I am greatly indebted to Dr D. A. Erasmus for his encouragement, advice and supervision during this investigation, and also for carrying out the experimental infections. I also wish to thank Professor J. Brough for the provision of excellent laboratory facilities. Many thanks are due to Mr J. H. M. Hughes (Veterinary Officer) and the meat inspectors at Roath Abattoir who provided me with infected material. I wish to acknowledge the financial support of the Pig Industry Development Authority and the Agricultural Research Council.

Type
Research Article
Copyright
Copyright © Cambridge University Press 1968

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References

REFERENCES

Beaver, P. C. & Little, M. D. (1964). The genital girdle in relation to estrus and mating in Ascaris lumbricoides. J. Parasit. 50, 128–30.CrossRefGoogle ScholarPubMed
Fülleborn, F. (1920). Ueber die Anpassung der Nematoden an der Parasitismus und den Infektionsweg bei Askaris und anderen Fadenwürmern des Menschen. Arch. Schiffs- u. Tropenhyg. 24, 340–7.Google Scholar
Fülleborn, F. (1927). Ueber das Verhalten der Larven von Strongyloides stercoralis, Hakenwürmern und Ascaris lumbricoides im Körper des Wirtes und ein Versuch, es biologisch zu deuten. Arch. Schiff- u. Tropenhyg. 31, (Beihefte 2), 151202.Google Scholar
Gray, P. (1954). The Microtomists Formulary and Guide, 794 pp. New York: Blakiston Comp. Inc.Google Scholar
Hill, C. H. (1957). Distribution of larvae of Trichinella spiralis in the organs of experimentally infected swine. J. Parasit. 43, 574–7.CrossRefGoogle ScholarPubMed
Lewert, R. M. & Lee, C. L. (1954). Studies on the passage of helminth larvae through host tissues. J. infect. Dis. 95, 1351.CrossRefGoogle ScholarPubMed
Ransom, B. H. & Cram, E. B. (1921). The course of migration of Ascaris larvae. Am. J. trop. Med. 1, 129–56.CrossRefGoogle Scholar
Ransom, B. H. & Foster, W. D. (1920). Observations on the life history of Ascaris lumbricoides. Bull. U.S. Dept. Agric. 817, 47 pp.Google Scholar
Roberts, F. H. S. (1934). The large roundworm of pigs Ascaris lumbricoides L., 1758. Its life history in Queensland, economic importance and control. Bull. Anim. Hlth Stn Yeerongpilly, Queensland no. 1.Google Scholar
Rogers, W. P. (1958). Physiology of the hatching of eggs of Ascaris lumbricoides. Nature, Lond. 181, 1310–11.CrossRefGoogle Scholar
Sprent, J. F. A. (1951). On the migratory behaviour of the larvae of various Ascaris species in mice. J. Parasit. 37, Suppl. 21 (Abstr.)Google Scholar
Sprent, J. F. A. (1952). On the migratory behaviour of the larvae of various Ascaris species in white mice. I. Distribution of larvae in tissues. J. infect. Dis. 90, 165–76.CrossRefGoogle ScholarPubMed
Sprent, J. F. A. (1964). The life cycles of nematodes in the family Ascarididae Blanchard 1896. J. Parasit. 40, 608–17.CrossRefGoogle Scholar
Stewart, F. H. (1917). On the development of Ascaris lumbricoides Lin. and Ascaris suilla Duj. in the rabbit and mouse. Parasitology 9, 213–27.CrossRefGoogle Scholar
Volkheimer, G., John, H. & Wolf, W. (1962). Beobachtungen uber einem bemerkenswerten Verschleppungsmechanismus von Ascarideneiern im Wirtsorganismus. Z. ParasitKde 22, 183–5.Google Scholar
Yoshida, S. (1919). On the migratory course of Ascarid larvae in the body of the host. J. Parasit. 6, 1927.CrossRefGoogle Scholar