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Novel anti-malarial hydroxynaphthoquinones with potent broad spectrum anti-protozoal activity

Published online by Cambridge University Press:  06 April 2009

A. T. Hudson ,
A. W. Randall ,
M. Fry ,
C. D. Ginger ,
B. Hill ,
V. S. Latter ,
N. McHardy  and
R. B. Williams
A. T. Hudson
Affiliation:
Department of Therapeutic Chemistry, Wellcome Research Laboratories, Langley Court, Beckenham, Kent BR3 3B8
A. W. Randall
Affiliation:
Department of Therapeutic Chemistry, Wellcome Research Laboratories, Langley Court, Beckenham, Kent BR3 3B8
M. Fry
Affiliation:
Department of Biochemical Parasitology, Wellcome Research Laboratories, Langley Court, Beckenham, Kent BR3 3B8
C. D. Ginger
Affiliation:
Department of Biochemical Parasitology, Wellcome Research Laboratories, Langley Court, Beckenham, Kent BR3 3B8
B. Hill
Affiliation:
Department of Biochemical Parasitology, Wellcome Research Laboratories, Langley Court, Beckenham, Kent BR3 3B8
V. S. Latter
Affiliation:
Department of Biochemical Parasitology, Wellcome Research Laboratories, Langley Court, Beckenham, Kent BR3 3B8
N. McHardy
Affiliation:
Department of Biochemical Parasitology, Wellcome Research Laboratories, Langley Court, Beckenham, Kent BR3 3B8
R. B. Williams
Affiliation:
Department of Veterinary Research, Weilcome Research Laboratories, Berkhamsted, Herts HP4 2QE
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Extract

Novel hydroxynaphthoquinones are reported with outstanding efficacy against Plasmodium, Eimeria and Theileria species. Biochemical evidence is presented for the selective toxicity of these compounds being due to inhibition of parasite respiratory systems.

Type
Research Article
Information
Parasitology , Volume 90 , Issue 1 , February 1985 , pp. 45 - 55
Copyright
Copyright © Cambridge University Press 1985

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References

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