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Non-specific induction of increased resistance in mice to Trypanosoma congolense and Trypanosoma brucei by immunostimulants

Published online by Cambridge University Press:  06 April 2009

Max Murray  and
W. I. Morrison
Max Murray
Affiliation:
International Laboratory for Research on Animal Diseases (ILRAD) P.O. Box 30709, Nairobi, Kenya
W. I. Morrison
Affiliation:
International Laboratory for Research on Animal Diseases (ILRAD) P.O. Box 30709, Nairobi, Kenya
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Summary

Administration of the immunostimulants Corynebacterium parvum, Bacillus Calmette-Guérin (BCG) or Bordetella pertussis prior to, or at the same time as, challenge with Trypanosoma congolense significantly increased survival times in mice, both of trypano-susceptible (A/J) and trypano-resistant (C57Bl) strains. The increased survival time was associated with significant alterations in parasitaemia, which included lengthening of the pre-patent period, a delay in the time taken to reach the first peak of parasitaemia and a reduction in the level of parasitaemia. Similar results were obtained when these strains of mice were challenged with Trypanosoma brucei following pre-treatment with C. parvum. Thus, by the use of immunostimulants it was possible to reduce the susceptibility of mice to trypanosomiasis and the hope is that this can also be achieved with domestic livestock.

Type
Research Article
Information
Parasitology , Volume 79 , Issue 3 , December 1979 , pp. 349 - 366
Copyright
Copyright © Cambridge University Press 1979

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