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Naturally occurring antibodies to the cuticle of nematodes

Published online by Cambridge University Press:  06 April 2009

R. S. Hogarth-Scott
R. S. Hogarth-Scott
Affiliation:
Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, England
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Extract

Studies based on the mixed antiglobulin reaction have shown that γ-globulin is adsorbed from normal human sera by the cuticle of parasitic nematodes. Using antiglobulins specific for IgA, IgM and IgG, it was possible to demonstrate uptake to titres of 4, 64 and 128, respectively. Adsorption continued for at least 24 h, and the responsible immunoglobulins could be absorbed from the sera by nematode preparations.

A comparison of normal human sera with sera from cases of ascariasis and visceral larva migrans revealed that there was no significant difference between the titre of anti-cuticular immunoglobulins in normal sera or sera from helmin-thiases. It is suggested that these immunoglobulins adsorbed by the nematode cuticle represent cross-reacting, naturally occurring antibodies.

I am sincerely grateful to Professor R. R. A. Coombs, F.R.S., for his help, advice and encouragement, and to Mr M. J. Eburne for splendid technical assistance.

Type
Research Article
Information
Parasitology , Volume 58 , Issue 1 , February 1968 , pp. 221 - 226
Copyright
Copyright © Cambridge University Press 1968

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References

REFERENCES

Boyden, S. V. (1966). Natural antibodies and the immune response. Adv. Immunol. 5, 1–24.Google ScholarPubMed
Coombs, R. R. A., Jonas, W. E., Lachmann, P. J. & Feinstein, A. (1965). Detection of IgA antibodies by the red cell linked antigen-antiglobulin reaction: antibodies in the sera of infants to milk proteins. Int. Arch. Allergy 27, 321–37.CrossRefGoogle ScholarPubMed
Coombs, R. R. A., Pout, D. D. & Soulsby, E. J. I. (1965). Globulin possibly of an antibody nature, combining with the cuticle of live Turbatrix aceti. Expl Parasit. 16, 311–17.CrossRefGoogle ScholarPubMed
Fairbairn, D. (1961). The in vitro hatching of Ascaris lumbricoides eggs. Can. J. Zool. 39, 153–62.CrossRefGoogle Scholar
Gell, P. G. N. & Coombs, R. R. A. (1963). Clinical Aspects of Immunology. Oxford: Blackwell Scientific Publication.Google Scholar
Hogarth-Scott, R. S. (1966). Visceral larva migrans—an immunofluorescent examination of rabbit and human sera for antibodies to the E.S. antigens of the second-stage larvae of Toxocara canis, Toxocara cati and Toxascaris leonina (Nematoda). Immunology 10, 217–23.Google Scholar
Hogarth-Scott, R. S. (1967). The immunology of nematode antigens, including the serodiagnosis of human visceral larva migrans. Ph.D. thesis, University of Cambridge.Google Scholar
Lee, D. L. (1965). The cuticle of adult Nippostrongylus brasiliensis. Parasitology 55, 173–81.CrossRefGoogle ScholarPubMed