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Molecular characterization of antigens of lymphatic filarial parasites

Published online by Cambridge University Press:  23 August 2011

M. E. Selkirk ,
D. A. Denham ,
F. Partono ,
I. Sutanto  and
R. M. Maizels
M. E. Selkirk
Affiliation:
Department of Pure and Applied Biology, Imperial College of Science and Technology, Prince Consort Road, London SW7 2BB
D. A. Denham
Affiliation:
London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 6BT
F. Partono
Affiliation:
Department of Parasitology, Faculty of Medicine, University of Indonesia, Salemba Raya, Jakarta, Indonesia
I. Sutanto
Affiliation:
Department of Parasitology, Faculty of Medicine, University of Indonesia, Salemba Raya, Jakarta, Indonesia
R. M. Maizels
Affiliation:
Department of Pure and Applied Biology, Imperial College of Science and Technology, Prince Consort Road, London SW7 2BB
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Extract

Three species of filarial worms, Wuchereria bancrofti, Brugia malayi and Brugia timori, are the causative agents of lymphatic filariasis in man, defined by the characteristic tropism of adult worms of each species for the afferent lymphatics. Reproductive activity leads to the release of large numbers of microfilariae, which circulate in the vascular system, and upon ingestion by an appropriate mosquito vector, develop through to infective third-stage larvae (L3) within 10–14 days. After a subsequent bloodmeal, the infective larvae enter the definitive host via the wound and mature to the adult stage over several months, involving two moults, during which the entire nematode exoskeleton (cuticle) is replaced.

Type
Research Article
Information
Parasitology , Volume 92 , supplement S1: Symposia of the British Society for Parasitology Volume 23 Parasites and molecular biology: applications of new techniques , January 1986 , pp. S15 - S38
Copyright
Copyright © Cambridge University Press 1986

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