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Molecular biology and electrophysiology of glutamategated chloride channels of invertebrates

Published online by Cambridge University Press:  06 April 2009

D. F. Cully ,
H. Wilkinson ,
D. K. Vassilatis ,
A. Etter  and
J. P. Arena
D. F. Cully*
Affiliation:
Department of Genetics and Molecular Biology and Department of Cell Biochemistry and Physiology, Merck Research Laboratories, PO 2000, Rahway, New Jersey 07065–0900, USA
*
*Corresponding author.
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Summary

In this chapter we summarize the available data on a novel class of ligand-gated anion channels that are gated by the neurotransmitter glutamate. Glutamate is classically thought to be a stimulatory neurotransmitter, however, studies in invertebrates have proven that glutamate also functions as an inhibitory ligand. The bulk of studies conducted in vivo have been on insects and crustaceans, where glutamate was first postulated to act on H-receptors resulting in a hyperpolarizing response to glutamate. Recently, glutamate-gated chloride channels have been cloned from several nematodes and Drosophila. The pharmacology and electrophysiological properties of these channels have been studied by expression in Xenopus oocytes. Studies on the cloned channels demonstrate that the invertebrate glutamate-gated chloride channels are the H-receptors and represent important targets for the antiparasitic avermectins.

Keywords

Glutamateavermectinchloride channelinvertebrates
Type
Research Article
Information
Parasitology , Volume 113 , supplement S1: Molecular biochemistry and physiology of helminth neuromuscular systems , January 1996 , pp. S191 - S200
Copyright
Copyright © Cambridge University Press 1996

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