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Migrational responses of Hymenolepis diminuta to surgical alteration of gastro-intestinal secretions

Published online by Cambridge University Press:  06 April 2009

M. V. K. Sukhdeo  and
D. F. Mettrick
M. V. K. Sukhdeo
Affiliation:
Department of Zoology, University of Toronto, Ontario, CanadaM5S 1A1
D. F. Mettrick
Affiliation:
Department of Zoology, University of Toronto, Ontario, CanadaM5S 1A1
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Summary

The effects of the direction of gut flow, of injections of glucose and saline into different regions of the small intestine and of surgical re-routing or ligature of gastric, biliary and pancreatic secretions into the small intestine have been correlated with changes in the migratory response of the rat tapeworm Hymenolepis diminuta. Reversing the normal anterior to distal flow of luminal contents in the small intestine did not affect worm migration following feeding. Injections of a glucose-saline solution into the duodenum did not initiate a migratory response; similar injections into the mid- and posterior regions of the small intestine resulted in migrational responses similar to those following intragastric glucose feeding. Re-routing gastric secretions to the distal duodenum inhibited anterior migration of the worms beyond the new point of entry of gastric juices. Results following re-routing and ligation of the biliary and pancreatic secretions suggest that there is a potent cue to anteriad migration in the pancreatic secretions. Biliary secretions also appear to contain an additional migratory cue to worm migration. In order of importance the factors stimulating/inhibiting worm migration are pancreatic > gastric > biliary > glucose. The results support the hypothesis that the factors affecting worm distribution in the small intestine are interactive and synergistic, involve other luminal factors, such as 5- hydroxytryptamine and the physico-chemical gradients, and are of a regional nature such that the migratory response of a particular worm is directly related to its position in the small intestine when the cues to relocation are received.

Type
Research Article
Information
Parasitology , Volume 88 , Issue 3 , June 1984 , pp. 421 - 430
Copyright
Copyright © Cambridge University Press 1984

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References

Alder, H. L. & Roessler, E. B. (1972). Introduction to Probability and Statistics. San Francisco: W. H. Freeman and Co.Google Scholar
Arai, H. P. (1980). Migratory activity and related phenomena in Hymenolepis diminuta. In Biology of the Tapeworm Hymenolepis diminuta (ed. Arai, H. P.), pp. 615–37. New York: Academic Press.Google Scholar
Cho, C. H. & Mettrick, D. F. (1982). Circadian variation in the distribution of Hymenolepis diminuta (Cestoda) of 5-HT (serotonin) levels in the gastrointestinal tract of the laboratory rat. Parasitology 84, 431–41.Google Scholar
Crompton, D. W. T. (1973). The sites occupied by some parasitic helminths in the alimentary tract of vertebrates. Biological Reviews 48, 27–83.Google Scholar
Dean, R. B. & Dixon, W. J. (1951). Simplified statistics for small numbers of observations. Analytical Chemistry 45, 636–8.Google Scholar
Dunkely, L. C. & Mettrick, D. F. (1977). Hymenolepis diminuta: migration, and the rat hosts intestinal and blood plasma glucose levels following dietary carbohydrate intake. Experimental Parasitology 41, 213–28.CrossRefGoogle Scholar
Hays, W. L. & Winkler, R. L. (1971). Statistics: Probability, Inference and Decision. New York: Holt, Rinehart and Winston Inc.Google Scholar
Hopkins, C. A. (1970). Diurnal movement of Hymenolepis diminuta in the rat. Parasitology 60, 255–7 1.Google Scholar
Hopkins, C. A. & Allen, L. M. (1979). Hymenolepis diminuta: the role of the tail in determining the position of the worm in the intestine of the rat. Parasitology 79, 401–10.Google Scholar
Mettrick, D. F. (1971). Effect of the host dietary constituents on intestinal pH and on the migrational behaviour of the rat tapeworm Hymenolepis diminuta. Canadian Journal of Zoology 49, 1513–25.Google Scholar
Mettrick, D. F. (1972). Changes in the distribution and chemical composition of Hymenolepis diminuta and the intestinal nutritional gradients of uninfeeted and parasitized rats following a glucose meal. Journal of Helminthology 46, 407–29.CrossRefGoogle ScholarPubMed
Mettrick, R. F. (1973). Competition for ingested nutrients between the tapeworm Hymenolepis diminuta and the rat host. Canadian Journal of Public Health 64, 70–82.Google ScholarPubMed
Mettrick, D. F. (1980). The intestine as an environment for Hymenolepis diminuta. In Biology of the Tapeworm Hymenolepis diminuta (ed. Arai, H. P.) pp. 281–356. New York: Academic Press.CrossRefGoogle Scholar
Mettrick, D. F. (1982). Behavioural physiological cues to cestodes with particular reference to serotonin (5-HT). In Cues which influence Behaviour of Parasites (ed. Bailey, S. W.), pp.85–109. New Orleans: U.S. Department of Agriculture.Google Scholar
Mettrick, D. F. & Cho, C. H. (1981). Hymenolepis diminuta: effect of electrical vagal stimulation on worm migration. Journal of Parasitology 67, 386–90.Google Scholar
Mettrick, D. F. & Cho, C. H. (1982). Changes in tissue and intestinal serotonin (5-HT) levels in the laboratory rat following feeding and the effect of 5-HT inhibitors on the migrating response of Hymenolepis diminuta (Cestoda). Canadian Journal of Zoology 60, 790–7.Google Scholar
Mettrick, D. F. & Podesta, R. B. (1974). Ecological and physiological aspects of helminth–host interactions in the mammalian gastrointestinal canal. In Advances in Parasitology, vol. 12 (ed Dawes, B.), pp. 183–278. New York: Academic Press.Google Scholar
Mettrick, D. F. & Podesta, R. B. (1982). Effect of gastrointestinal hormones and amines on intestinal motility and the migration of Hymenolepis diminuta in the rat small intestine. International Journal for Parasitology 12, 151–4.Google Scholar
Mettrick, D. F., Rahman, M. S. & Podesta, R. B. (1981). Effect of 5-hydroxytryptamine (5-HT, serotonin) on in vitro glucose uptake and glycogen reserves in Hymenolepis diminuta. Molecular and Biochemical Parasitology 4, 217–24.Google Scholar
Podesta, R. B., Stallard, H. E., Evans, W. S., Lussier, P., Jackson, D. & Mettrick, D. F. (1977). Determination of unidirectional uptake rates for non-electrolytes across the epithelial membrane of Hymenolepis diminuta. Experimental Parasitology 42, 300–17.CrossRefGoogle Scholar
Rahman, M. S., Mettrick, D. F. & Podesta, R. B. (1983). Effect of 5-hydroxytryptamine on carbohydrate metabolism in Hymenolepis diminuta (Cestoda). Canadian Journal of Physiology and Pharmacology 61, 137–43.Google Scholar
Read, C. P. & Kilejian, A. Z. (1969). Circadian migratory behaviour of a cestode symbiote in the rat host. Journal of Parasitology 55, 574–8.CrossRefGoogle ScholarPubMed
Roberts, T. M. (1982). From receptor to response: prospects for research in behavioural parasitology. In Cues which Influence Behaviour of Parasites (ed. Bailey, W. S.), pp. 166–79. U.S. New Orleans: Department of Agriculture.Google Scholar
Sukhdeo, M. V. K. & Mettrick, D. F. (1983). Site selection by Heligmosomoides polygyrus (Nematoda): effects of surgical alteration of the gastrointestinal tract. International Journal for Parasitology 13, 355–8.CrossRefGoogle ScholarPubMed