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Lymphoreticular responses to metacestodes: Taenia multiceps (Cestoda) can modify interaction between accessory cells and responder cells during lymphocyte activation

Published online by Cambridge University Press:  06 April 2009

N. K. Rakha ,
J. B. Dixon ,
G. C. Skerritt ,
S. D. Carter ,
P. Jenkins  and
S. Marshall-Clarke
N. K. Rakha
Affiliation:
Departments of Veterinary Pathology, University of Liverpool, P.O. Box 147, Liverpool L69 3BX
J. B. Dixon
Affiliation:
Departments of Veterinary Pathology, University of Liverpool, P.O. Box 147, Liverpool L69 3BX
G. C. Skerritt
Affiliation:
Veterinary Preclinical Sciences, University of Liverpool, P.O. Box 147, Liverpool L69 3BX
S. D. Carter
Affiliation:
Departments of Veterinary Pathology, University of Liverpool, P.O. Box 147, Liverpool L69 3BX
P. Jenkins
Affiliation:
Departments of Veterinary Pathology, University of Liverpool, P.O. Box 147, Liverpool L69 3BX
S. Marshall-Clarke
Affiliation:
Human Anatomy and Cell Biology, University of Liverpool, P.O. Box 147, Liverpool L69 3BX
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Summary

This study was designed to test the accessory function of macrophages after activation with products of Taenia multiceps coenuri. Activation was carried out by intraperitoneal injection of mice with coenurus fluid or protoscolex culture supernatant, and function was assessed by adding these macrophages in progressively increasing numbers to macrophage-depleted lymphocyte cultures transforming under the influence of plant mitogens or coenurus-fluid mitogen. In contrast to normal macrophages, which have a progressively enhancing action on the above reactions, parasite-activated macro-phages at similar concentrations were progressively inhibitory. However, low concentrations of the activated macrophages enhanced mitosis as well as, or better than, normal. Lymph node cells from injected mice showed abnormal response to macrophage-derived signals. In particular there was subnormal reaction to macrophages in the presence of coenurus mitogen. These results suggest that T. multiceps coenuri may survive in the host because of their ability to reduce effective interaction between lymphocytes and accessory cells.

Keywords

Taenia multicepsmacrophageT-celltransformationaccessory cell
Type
Research Article
Information
Parasitology , Volume 102 , Issue 1 , February 1991 , pp. 133 - 140
Copyright
Copyright © Cambridge University Press 1991

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