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Latent infections in avian malaria in relation to the production of drug-resistance

Published online by Cambridge University Press:  06 April 2009

Elspeth W. McConnachie
Elspeth W. McConnachie
Affiliation:
Molteno Institute, University of Cambridge
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Extract

1. No resistance to paludrine or to sulphadiazine was obtained after treating latent infections of Plasmodium gallinaceum in chickens with twice daily doses of 20 mg./20 g. of sulphadiazine over periods of 171, 178 and 190 days.

2. No resistance to paludrine was obtained after treating a latent infection of P. relictum in a canary over a period of 1 year with doses of paludrine increasing from 0·05 mg./20 g. once daily to 1·0 mg./ 20 g. twice daily.

3. It is considered that if drug-resistance arises by mutation and selection, then resistance should arise more readily when a large number of rapidly multiplying parasites is treated with a drug than when the population treated is small, with a low reproduction rate, i.e. the failure to obtain resistant strains of malaria by prolonged treatment of latent infections with large amounts of drug, lends support to the theory of the origin of resistant strains of malaria by the selection of resistant mutants.

Type
Research Article
Information
Parasitology , Volume 41 , Issue 1-2 , July 1951 , pp. 110 - 116
Copyright
Copyright © Cambridge University Press 1951

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