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Is there an association of Pneumocystis infection with the presence of arena-, hanta-, and poxvirus antibodies in wild mice and shrews in Finland?

Published online by Cambridge University Press:  25 November 2005

J. LAAKKONEN ,
E. R. KALLIO ,
H. KALLIO-KOKKO ,
O. VAPALAHTI ,
A. VAHERI  and
H. HENTTONEN
J. LAAKKONEN
Affiliation:
Department of Virology, Haartman Institute, P.O. Box 21, FIN-00014 University of Helsinki, Finland Finnish Forest Research Institute, Vantaa, Finland
E. R. KALLIO
Affiliation:
Department of Virology, Haartman Institute, P.O. Box 21, FIN-00014 University of Helsinki, Finland Finnish Forest Research Institute, Vantaa, Finland Department of Basic Veterinary Sciences, Faculty of Veterinary Medicine, P.O. Box 66, FIN-00014 University of Helsinki, Finland
H. KALLIO-KOKKO
Affiliation:
Department of Virology, Haartman Institute, P.O. Box 21, FIN-00014 University of Helsinki, Finland Department of Virology, HUSLAB, P.O. Box 400, FIN-00029 The Hospital District of Helsinki and Vusima, Finland
O. VAPALAHTI
Affiliation:
Department of Virology, Haartman Institute, P.O. Box 21, FIN-00014 University of Helsinki, Finland Department of Virology, HUSLAB, P.O. Box 400, FIN-00029 The Hospital District of Helsinki and Vusima, Finland
A. VAHERI
Affiliation:
Department of Virology, Haartman Institute, P.O. Box 21, FIN-00014 University of Helsinki, Finland
H. HENTTONEN
Affiliation:
Finnish Forest Research Institute, Vantaa, Finland
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Abstract

As part of studies on the nature of the endemic virus infections in natural rodent hosts, the possible association of cyst forms of Pneumocystis spp. with the presence of hanta-, cowpox-, and arenavirus antibodies in wild mice (Apodemus flavicollis, N=105; Apodemus agrarius, N=63; Micromys minutus, N=50) and the common shrew (Sorex araneus, N=101) was studied in south-central Finland. One hantavirus (Saaremaa virus, SAAV) seropositive A. agrarius, and 2 cowpoxvirus (CPXV) seropositive S. araneus were detected, and antibodies against an arenavirus (Lymphocytic choriomeningitis virus, LCMV) were found in all 3 mouse species but not in shrews. Cyst forms of Pneumocystis spp. were detected in all species except A. agrarius. There was no significant association between virus antibodies (LCMV in mice, and CPXV in shrews) and cyst forms of Pneumocystis in any of the species. Concurrent presence of virus antibodies (LCMV) and cyst forms of Pneumocystis were detected only in 1 M. minutus. In conclusion, we found no evidence of any association between Pneumocystis and antibodies to any of the viruses tested.

Keywords

Pneumocystishantaviruspoxvirusarenavirusrodentsvolesmiceshrews
Type
Research Article
Information
Parasitology , Volume 132 , Issue 4 , April 2006 , pp. 461 - 466
Copyright
2005 Cambridge University Press

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