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Intake of nutrient supplements affects multiplication of Leishmania donovani in hamsters

Published online by Cambridge University Press:  18 November 2004

RAVENDRA GARG ,
NIRPENDRA SINGH  and
ANURADHA DUBE
RAVENDRA GARG
Affiliation:
Division of Parasitology, Central Drug Research Institute, PO Box 173, Lucknow – 226001, India
NIRPENDRA SINGH
Affiliation:
Division of Parasitology, Central Drug Research Institute, PO Box 173, Lucknow – 226001, India
ANURADHA DUBE
Affiliation:
Division of Parasitology, Central Drug Research Institute, PO Box 173, Lucknow – 226001, India
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Abstract

The role of the essential nutrients, vitamins A,B (complex), C and E and iron, as prophylactic as well as supportive therapy in experimental visceral leishmaniasis (VL), was studied in hamsters. Prophylactic administration of vitamin C (50, 100 and 250 mg/kg) from day15 to day 0 (15 doses) significantly reduced the intake of Leishmania donovani in hamsters but had no therapeutic effect. In contrast, vitamins A,B complex and E and iron, whether used prophylactically or therapeutically, promoted parasite multiplication. The efficacy of sodium stibogluconate, a reference antileishmanial drug, was appreciably improved in animals administered prophylactically with vitamin C. However, supplementation of vitamin C during established infections resulted in reduced drug action. The results show that the prophylactic use of vitamin C may prevent the onset of leishmania infection and cautions against the indiscriminate use of nutrient supplements such as vitamin A, B complex, and E and iron in VL endemic areas.

Keywords

Leishmania donovanihamstervitamin Avitamin B complexvitamin Cvitamin Eironsodium stibogluconate
Type
Research Article
Information
Parasitology , Volume 129 , Issue 6 , December 2004 , pp. 685 - 691
Copyright
© 2004 Cambridge University Press

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