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Immunity to primary and challenge infections of Trichinella spiralis in mice: a re-examination of conventional parameters

Published online by Cambridge University Press:  06 April 2009

D. Wakelin  and
M. Lloyd
D. Wakelin
Affiliation:
Wellcome Laboratories for Experimental Parasitology, University of Glasgow, Bearsden Road, Glasgow, G61 1QH
M. Lloyd
Affiliation:
Wellcome Laboratories for Experimental Parasitology, University of Glasgow, Bearsden Road, Glasgow, G61 1QH
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Extract

In young (6- to 8-week-old) NTH strain inbred mice expulsion of a primary infection of Trichinella spiralis began on day 8 and was virtually complete by day 11·5. In older mice expulsion occurred 1 or 2 days earlier. Experience of a primary infection elicited strong immunity to challenge, whether the challenge was given immediately after worm expulsion (day 14) or delayed (day 42). Challenge infections were expelled rapidly, the majority of worms being lost during the first day. Immunity to challenge was elicited by low-level primary infections and was effective against large challenge infections. These results are discussed in relation to conventionally accepted parameters of immunity to T. spiralis in mice which, it is considered, are applicable only to mice with a genetically-determined low-level of responsiveness to the parasite.

Type
Research Article
Information
Parasitology , Volume 72 , Issue 2 , April 1976 , pp. 173 - 182
Copyright
Copyright © Cambridge University Press 1976

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References

Bass, G. K. & Olson, L. J. (1965). Trichinella spiralis in new born mice: course of infection and effect on resistance to challenge. Journal of Parasitology 51, 640–4.CrossRefGoogle Scholar
Campbell, W. C. (1967). Distribution of Trichinella spiralis in the small intestine of young mice. Journal of Parasitology 53, 395–7.CrossRefGoogle ScholarPubMed
Campbell, W. C., Hartman, R. K. & Cuckler, A. C. (1963 a). Effect of certain antihistamine and antiserotonin agents upon experimental trichinosis in mice. Experimental Parasitology 14, 23–8.CrossRefGoogle ScholarPubMed
Campbell, W. C, Hartman, R. K. & Cuckler, A. C. (1963). Induction of immunity to trichinosis in mice by means of chemically abbreviated infections. Experimental Parasitology 14, 29–36.CrossRefGoogle ScholarPubMed
Crandall, R. B. & Crandall, C. A. (1972). Trichinella spiralis: immunologic response to infection in mice. Experimental Parasitology 31, 378–98.CrossRefGoogle ScholarPubMed
Culbertson, J. T. (1942). Active immunity in mice against Trichinella spiralis. Journal of Parasitology 28, 197–206.CrossRefGoogle Scholar
Denham, D. A. (1966). Immunity to Trichinella spiralis. II. Immunity produced by the adult worm in mice. Parasitology 56, 745–51.CrossRefGoogle ScholarPubMed
Denham, D. A. (1968). Immunity to Trichinella spiralis. III. The longevity of the infection in mice. Journal of Helminthology 42, 257–68.CrossRefGoogle Scholar
Denham, D. A. & Martinez, A. R. (1970). Studies with methyridine and Trichinella spiralis. II. The use of the drug to study the rate of larval production in mice. Journal of Helminthology 44, 357–63.CrossRefGoogle Scholar
Despommier, D. D. & Wostmann, B. S. (1968). Diffusion chambers for inducing immunity to Trichinella spiralis in mice. Experimental Parasitology 23, 228–33.CrossRefGoogle ScholarPubMed
Dinetta, J., Katz, F. & Campbell, W. C. (1972). Effect of heterologous antilymphocyte serum on the spontaneous cure of Trichinella spiralis infections in mice. Journal of Parasitology 58, 636–7.CrossRefGoogle ScholarPubMed
Febnandez, A. M., Campillo, M. C. Del & Gancedo, B. A. (1969). Studies on the immunological tolerance to Trichinella spiralis infection in rats. Wiadomosci Parazytologiczne 15, 585–96.Google Scholar
Fischthal, J. H. (1943). Number of larvae and time required to produce active immunity in rats against Trichinella spiralis. Journal of Parasitology 29, 123–6.CrossRefGoogle Scholar
Gore, R. W., Bürger, H.-J. & Sadun, E. H. (1974). Humoral and cellular factors in the resistance of rats to Trichinella spiralis. In Trichinellosis (ed. Kim, C. W.), pp. 367–82. New York: Intext Educational Publishers.Google Scholar
Gursch, O. F. (1949). Intestinal phase of Trichinella spiralis (Owen, 1835) Railliet 1895. Journal of Parasitology 25, 19–26.CrossRefGoogle Scholar
Hendricks, J. R. (1952). Studies in mice on the dual antibody basis of acquired resistance to Trichinella spiralis. Journal of the Elisha Mitchell Scientific Society 68, 12–36.Google Scholar
Karmanska, K., Michalska, Z. & Dlugiewicz-Bulla, M. (1973). Influence of compound 48/80 on Trichinella spiralis infection in rats. Acta Parasitica Polonica 21, 513–41.Google Scholar
Kozar, M. (1973). Investigations on the induction and inhibition of immunity in mice infected with Trichinella spiralis. Acta Parasitica Polonica 21, 115–71.Google Scholar
Larsh, J. E. (1963). Experimental trichiniasis. Advances in Parasitology 1, 213–86.CrossRefGoogle ScholarPubMed
Love, R. J., Ogilvie, B. M. & McLaben, D. J. (1976). The immune mechanism which expels the intestinal stage of Trichinella spiralis from rats. Immunology (in the Press).Google Scholar
Machnicka, B. (1972). Trichinella spiralis: influence of antilymphocytic serum on mouse infections. Experimental Parasitology 31, 172–7.CrossRefGoogle ScholarPubMed
McCoy, O. R. (1938). Rapid loss of Trichinella spiralis fed to immune rats and its bearing on the mechanism of immunity. Journal of Parasitology 24 (suppl.), 35.Google Scholar
Olson, L.J. & Richardson, J. A. (1968). Intestinal malabsorption in mice infected with Trichinella spiralis. Journal of Parasitology 54, 445–51.CrossRefGoogle ScholarPubMed
Rappaport, I. & Wells, H. S. (1951). Studies in trichinosis. I. Immunity to reinfection in mice following a single light infection. Journal of Infectious Diseases 88, 248–53.CrossRefGoogle ScholarPubMed
Ruitenberg, E. J. (1974). Immunological aspects of Trichinella spiralis infection in the rat. In Trichinellosis (ed. Kim, C. W.), pp. 205–12. New York: Intext Educational Publishers.Google ScholarPubMed
Ruitenberg, E. J. & Steerenberg, P. A. (1974). Intestinal phase of Trichinella spiralis in congenitally athymic (nude) mice. Journal of Parasitology 60, 1056–7.CrossRefGoogle ScholarPubMed
Stefanski, W. & Kozar, M. (1969). Degree of resistance of some mouse strains to Trichinella spiralis infection. Wiadomości Parazytologiczne 15, 571–5.Google ScholarPubMed
Stoner, R. D. & Hale, W. M. (1952). Effect of Cobalt60 gamma radiation on susceptibility and immunity to trichinosis. Proceedings of the Society for Experimental Biology and Medicine 80, 510–12.CrossRefGoogle ScholarPubMed
Wakelin, D. (1975 a). Genetic control of immune responses to parasites: immunity to Trichuris muris in inbred and random-bred strains of mice. Parasitology 71, 51–60.CrossRefGoogle ScholarPubMed
Wakelin, D. (1975 b). Genetic control of immune responses to parasites: selection for responsiveness and non-responsiveness to Trichuris muris in random-bred mice. Parasitology 71, 377–84.CrossRefGoogle ScholarPubMed