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Host-parasite relationship between congenital Toxoplasma infection and mouse brain: role of small vessels

Published online by Cambridge University Press:  06 April 2009

T. A. Sims  and
J. Hay
T. A. Sims
Affiliation:
University Department of Pathology, Leicester Royal Infirmary, Leicester LE2 7LX
J. Hay
Affiliation:
Tennent Institute of Ophthalmology, University of Glasgow, Western Infirmary, 38 Church Street, Glasgow G11 6NT
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Summary

Small vessels showing inflammatory cell infiltrates were invariably observed in the vicinity of intact Toxoplasma tissue cysts within the brains of mice congenitally infected with the protozoan. Lymphocytes were observed in intimate contact with the luminal aspect of the endothelium, penetrating into the thickened basal lamina and in the perivascular area, which also contained macrophages and neutrophilic granulocytes. Rarely, lymphocytes were observed attached to the outer membrane of the host neurone which contained a Toxoplasma tissue cyst and within the inflammatory infiltrate associated with a disintegrating cyst. An hypothesis is presented which combines these morphological observations to explain the events associated with tissue cyst associated recrudescence of latent Toxoplasma infection in mouse brain.

Keywords

Toxoplasmacongenital infectionmouse brainsmall vesselstissue cystsrecrudescence
Type
Research Article
Information
Parasitology , Volume 110 , Issue 2 , February 1995 , pp. 123 - 127
Copyright
Copyright © Cambridge University Press 1995

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