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Haematological alterations in non-human hosts infected with Trypanosoma cruzi: a systematic review

Published online by Cambridge University Press:  02 August 2018

Evaristo Villalba-Alemán ,
David L. Justinico ,
Mariáurea M. Sarandy ,
Rômulo D. Novaes ,
Mariella B. Freitas  and
Reggiani V. Gonçalves Open the ORCID record for Reggiani V. Gonçalves [Opens in a new window]
Evaristo Villalba-Alemán
Affiliation:
Department of Animal Biology, Federal University of Viçosa, Viçosa, Minas Gerais, Brazil
David L. Justinico
Affiliation:
Department of Animal Biology, Federal University of Viçosa, Viçosa, Minas Gerais, Brazil
Mariáurea M. Sarandy
Affiliation:
Department of Animal Biology, Federal University of Viçosa, Viçosa, Minas Gerais, Brazil
Rômulo D. Novaes
Affiliation:
Department of Structural Biology, Federal University of Alfenas, Alfenas, Minas Gerais, Brazil
Mariella B. Freitas
Affiliation:
Department of Animal Biology, Federal University of Viçosa, Viçosa, Minas Gerais, Brazil
Reggiani V. Gonçalves*
Affiliation:
Department of Animal Biology, Federal University of Viçosa, Viçosa, Minas Gerais, Brazil
*
Author for correspondence: Reggiani V. Gonçalves, E-mail: [email protected]
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Abstract

American trypanosomiasis is a neglected tropical disease whose spectrum has not been quite understood, including the impact of Trypanosoma cruzi infection on the haematological parameters of different vertebrate hosts. Thus, this study was designed to compare the pattern of haematological changes induced by T. cruzi infection in order to identify possible species-specific differences among taxons. We also aimed at evaluating the use of this parameter as a tool for diagnosis during the acute phase, when symptoms are usually masked. For this purpose, we performed a systematic search on PubMed and Scopus databases to retrieve original studies published until August 2016. Thirty-one studies were selected using Prisma strategy, which were then submitted to data extraction and methodological bias analysis. Half of the studies showed that the number of erythrogram decreased in infected animals, indicating anaemia. In 68.2% of the studies, the total amount of leukogram values increased, suggesting infection. The main methodological limitations were insufficient information for T. cruzi strains identification, inoculation routes and parasitological characterization. Most of the mammalian species analysed showed the same pattern of haematological changes following T. cruzi infection, indicating that haematological parameters might direct the diagnosis of Chagas disease in the initial phase.

Keywords

Chagas diseaseerythrocyteshaematologyleucocytesTrypanosoma cruzi
Type
Review Article
Information
Parasitology , Volume 146 , Issue 2 , February 2019 , pp. 142 - 160
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Copyright © Cambridge University Press 2018 

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