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Genetic influences upon eosinophilia and resistance in mice infected with Mesocestoides corti

Published online by Cambridge University Press:  06 April 2009

D. A. Lammas ,
L. A. Mitchell  and
D. Wakelin
D. A. Lammas
Affiliation:
MRC Experimental Parasitology Group, Department of Zoology, University of Nottingham, University Park, NottinghamNG7 2RD
L. A. Mitchell
Affiliation:
MRC Experimental Parasitology Group, Department of Zoology, University of Nottingham, University Park, NottinghamNG7 2RD
D. Wakelin
Affiliation:
MRC Experimental Parasitology Group, Department of Zoology, University of Nottingham, University Park, NottinghamNG7 2RD
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Extract

The genetic influences upon host variation in eosinophilia and resistance to helminth infection, and the relationship between these parameters, was investigated in 9 inbred and 3 hybrid strains of mice infected with Mesocestoides corti. Blood, bone marrow, spleen and peritoneal fluid eosinophilia were far higher in SJL mice than in any other inbred strain. SWR, NIH, C3H and BALB/c mice were high responders to M. corti whereas CBA and 3 congenic strains sharing the B10 background (C57BL/10, B10.S, B10.G) were low responders. Some of the genes for high eosinophil responsiveness appeared to be dominant, as F1 hybrids from high and low response parental strains were intermediate to high in response to infection. SJL and NIH strains were highly susceptible to infection with M. corti, larval burdens at 21 days after infection with 100 tetrathyridia being considerably higher (>1000) than all other strains. BALB/c (≃ 700 larvae) were designated susceptible, SWR (>400 larvae) were resistant and the BIO congenics (<400 larvae) were highly resistant. Genes influencing resistance also appeared to be dominant, as F1 hybrids between resistant and susceptible parental strains were intermediate to resistant on infection. The overall response patterns indicate a direct correlation between susceptibility to infection and high eosinophil responsiveness, but this relationship is not consistent in all strains.

Keywords

Mesocestoides cortieosinophiliagenetic variationresistanceinbred mice
Type
Research Article
Information
Parasitology , Volume 101 , Issue 2 , October 1990 , pp. 291 - 299
Copyright
Copyright © Cambridge University Press 1990

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References

Amagai, T. & Cinader, B. (1981). Resistance against tolerance induction in SJL mice. Immunological Communications 10, 349–58.CrossRefGoogle ScholarPubMed
Butterworth, A. E. (1984). Cell-mediated damage to helminths. Advances in Parasitology 23, 143–235.CrossRefGoogle ScholarPubMed
Colley, D. G. (1974). Variations in peripheral blood eosinophil levels in normal and Schistosoma mansoni infected mice. Journal of Laboratory and Clinical Medicine 83, 871–6.Google ScholarPubMed
Cooke, A. & Hutchings, P. (1984). Defective regulation of erythrocyte auto-antibodies in SJL mice. Immunology 51, 489–92.Google Scholar
Festing, F. W. & Blackwell, M. (1988). Determination of mode of inheritance of host response. In Genetics of Resistance to Bacterial and Parasitic Infection (ed. Wakelin, D. & Blackwell, J. M.), pp. 21–61London: Taylor and Francis Ltd.Google Scholar
Hutchings, P. R., Varey, A. M. & Cooke, A. (1986). Immunological defects in SJL mice. Immunology 59, 445–50.Google ScholarPubMed
Johnson, G. R. & Metcalf, D. (1980). Detection of a new type of mouse eosinophil colony by Luxol-Fast-blue staining. Experimental Haematology 8, 549–61.Google ScholarPubMed
Kowalski, J. C. & Thorson, R. E. (1972). Protective immunity against tetrathyridia of Mesocestoides corti by passive transfer of serum in mice. Journal of Parasitology 58, 244–6.CrossRefGoogle ScholarPubMed
Lammas, D. A., Mitchell, L. A. & Wakelin, D. (1987). Adoptive transfer of enhanced eosinophilia and resistance to infection by an in vitro generated T cell-line specific for Mesocestoides corti larval antigen. Parasite Immunology 9, 591–601.CrossRefGoogle Scholar
Lammas, D. A., Mitchell, L. A. & Wakelin, D. (1988). Genetic control of eosinophilia in parasitic infections: responses of mouse strains to treatment with cyclophosphamide and parasitic antigen. International Journal for Parasitology 18, 1077–85.CrossRefGoogle Scholar
Lammas, D. A., Mitchell, L. A. & Wakelin, D. (1989). Genetic control of eosinophilia. Analysis of production and response to eosinophil differentiation factor in strains of mice infected with Trichinella spiralis. Clinical and Experimental Immunology 77, 137–43.Google ScholarPubMed
Novak, M. (1975). Cortisone and the growth of populations of Mesocestoides tetrathyridia in mice. International Journal for Parasitology 5, 517–20.CrossRefGoogle ScholarPubMed
Novak, M. (1977). Transfer of immunity to Mesocestoides corti infection by spleen cells. Journal of Parasitology 63, 587–8.CrossRefGoogle ScholarPubMed
O'garra, A. O. & Sanderson, C. J. (1987). Eosinophil Differentiation Factor and its associated B-cell growth factor activities. In Lymphokines and Interferons a Practical Approach (ed. Clemens, M. J., Morris, A. G. & Gearing, A. J. H.), pp. 323–344. Oxford: IRL Press.Google Scholar
Ottesen, E. A. (1985). Filariases and tropical eosinophilia. In Tropical and Geographical Medicine (ed. Warren, K. S. & Mahmoud, A. F.), pp. 390–412. New York: McGraw Hill.Google Scholar
Pollacco, S., Nicholas, W. L., Mitchell, G. F. & Stewart, A. C. (1978). T-cell dependent collagenous encapsulating response in the mouse liver to Mesocestoides corti (Cestoda). International Journal for Parasitology 8, 457–62.CrossRefGoogle ScholarPubMed
Sher, A., Coffman, R. L., Hieny, S., Scott, P. A. & Cheever, A. W. (1990). Interleukin-5 (IL-5) is required for the blood and tissue eosinophilia but not granuloma formation induced by infection with Schistosoma mansoni. Proceedings of the National Academy of Sciences, USA (in the Press).CrossRefGoogle Scholar
Specht, D. & Voge, M. (1965). Asexual multiplication of Mesocestoides tetrathyridia in laboratory animals. Journal of Parasitology 51, 268–72.CrossRefGoogle ScholarPubMed
Spry, C. J. F. (1988). Eosinophils. Oxford: Oxford University Press.Google Scholar
Strath, M. & Sanderson, C. J. (1986). Detection of eosinophil differentiation factor and its relationship to eosinophilia in Mesocestoides corti-infected mice. Experimental Hematology 14, 16–20.Google ScholarPubMed
Sugane, K. & Oshima, T. (1984). Interrelationship of eosinophilia and IgE antibody production to larval ES antigen in Toxocara canis infected mice Parasite Immunology 6, 409–20.CrossRefGoogle ScholarPubMed
Vadas, M. A. (1980). Parasite immunity and the major histocompatability complex. Immunogenetics 11, 215–33.CrossRefGoogle Scholar
Vadas, M. A. (1981). Cyclophosphamide pretreatment induces eosinophilia to non-parasite antigens. Journal of Immunology 127, 2083–6.CrossRefGoogle Scholar
Vadas, M. A. (1982). Genetic control of eosinophilia in mice: gene(s) expressed in bone marrow-derived cells control high responsiveness. Journal of Immunology 128, 691–5.CrossRefGoogle ScholarPubMed
Wakelin, D. (1988). Helminth infection. In Genetics of Resistance to Bacterial and Parasitic Infection (ed. Wakelin, D. & Blackwell, J. M.), pp. 153–224. London: Taylor and Francis Ltd.Google Scholar
Wakelin, D. & Donachie, A. M. (1983). Genetic control of eosinophilia. Mouse strain variation in response to antigens of parasite origin. Clinical and Experimental Immunology 51, 329–46.Google ScholarPubMed
White, T. R., Thompson, R. C. A. & Penhale, W. J. (1982). A comparative study of the susceptibility of inbred strains of mice to infection with Mesocestoides corti. International Journal for Parasitology 12, 29–33.CrossRefGoogle ScholarPubMed
White, T. R., Thompson, R. C. A. & Penhale, W. J. (1983). The effects of selective immunosuppression on resistance to Mesocestoides corti in strains of mice showing high and low initial susceptibility. Zeitschrift für Parasitenkunde 69, 91–104.CrossRefGoogle ScholarPubMed
White, I. R., Thompson, R. C. A. & Penhale, W. J. (1988). Studies on BCG immunotherapy in mice infected with Mesocestoides corti. International Journal for Parasitology 18, 389–93.CrossRefGoogle ScholarPubMed