Hostname: page-component-78c5997874-v9fdk Total loading time: 0 Render date: 2024-11-05T03:38:18.344Z Has data issue: false hasContentIssue false
  • English
  • Français

Fine structural changes in Eimeria tenella, from infections in chick embryos and chickens, after exposure to the anticoccidial drug robenidene

Published online by Cambridge University Press:  06 April 2009

D. L. Lee  and
B. J. Millard
D. L. Lee
Affiliation:
Houghton Poultry Research Station, Houghton, Huntingdon
B. J. Millard
Affiliation:
Houghton Poultry Research Station, Houghton, Huntingdon
Get access Rights & Permissions [Opens in a new window]

Extract

The structure of the various stages of Eimeria tenella grown in the chorioallantoic membranes of the chick embryo has been shown to be similar to the stages in the caecum of the bird. The effects of the anticoccidial drug, Robenidine, on the fine structure of the various stages of E. tenella, grown in the chick embryo and in the caecum of the bird, have been described. The first noticeable change occurs in the endoplasmic reticulum, including the nuclear envelope, and in the Golgi complexes of all stages. The nucleus itself, and the mitochondria, do not appear to be affected by the drug until much later, and this effect is probably due to the degeneration of the cell. It is suggested that the drug may have a direct effect upon protein metabolism of the parasite, resulting in swelling of the granular endoplasmic reticulum and Golgi complexes, or that it may have a primary effect upon some other organelle or metabolic process, and that the swelling of the endoplasmic reticulum and Golgi complexes is a secondary or tertiary phenomenon.

Type
Research Article
Information
Parasitology , Volume 65 , Issue 2 , October 1972 , pp. 309 - 316
Copyright
Copyright © Cambridge University Press 1972

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Aikawa, M., & Beaudoin, R. L., (1969). Morphological effects of 8 aminoquinolines on the exo-erythrocytic stages of Plasmodium fallax. Military medicine 134, 986–99.CrossRefGoogle Scholar
Beaudoin, R. L., Strome, C. P. A., & Clutter, W. G., (1969). A tissue culture system for the study of drug action against the tissue phase of malaria. Military medicine 134, 979–85.CrossRefGoogle Scholar
Delain, E., Brack, C. H., Riou, G., & Festy, B., (1970). Ultrastructure of trypanosomes treated with trypanosides: selective effects on cytoplasmic D.N.A. The Journal of Parasitology 56, 416.Google Scholar
Freeman, B. H., (1963). The gaseous metabolism of the domestic chicken. The oxygen requirements of the chicken during the period of rapid growth. British Poultry Science 4, 169–78.CrossRefGoogle Scholar
Gordon, A. B., Miller, L. R., & Bensch, K. G., (1963). Fixation of tissue culture cells for ultrastructural cytochemistry. Experimental Cell Research 31, 440–443.CrossRefGoogle ScholarPubMed
Howells, R. E., Peters, W., & Fullard, J., (1969). Cytochrome oxidase activity in a normal and some drug resistant strains of Plasmodium berghei — a cytochemical study. 1. Asexual erythrocytic stages. Military medicine 134, 893–915.CrossRefGoogle Scholar
Howells, R. E., Peters, W., & Fullard, J., (1970). The chemotherapy of rodent malaria. XIII. Fine structural changes observed in the erythrocytic stages of Plasmodium berghei berghei following exposure to primaquine and menoctone. Annals of Tropical Medicine and Parasitology 64, 203–7.CrossRefGoogle Scholar
Kantor, S., Kennett, R. L., Waletsky, E., & Tomcufcik, A. S., (1970). 1,3 bis (p-chlorobenzylideneamino)guanidine hydrochloride (Robenzidene). New Poultry anticoccidial agent. Science, New York 168, 373–4.CrossRefGoogle Scholar
Long, P. L., (1965). Development of Eimeria tenella in avian embryos. Nature, London 208, 509–10.CrossRefGoogle ScholarPubMed
Long, P. L., (1966). The growth of some species of Eimeria in avian embryos. Parasitology 56, 575–81.CrossRefGoogle ScholarPubMed
Long, P. L., (1970 a). Eimeria tenella. Chemotherapeutic studies in chick embryos with a description of a new method (chorioallantoic membrane foci counts) for evaluating infections. Zeitschrift für Parasitenkunde 33, 329–38.CrossRefGoogle ScholarPubMed
Long, P. L., (1970 b). Some factors affecting the severity of infection with Eimeria tenella in chicken embryos. Parasitology 60, 435–47.CrossRefGoogle ScholarPubMed
Macadam, R. F., & Williamson, J., (1967). The effect of drugs on the fine structure of trypanosomes. Parasitology 57, 21P.Google ScholarPubMed
McLaren, D. J., (1969). Observations on the fine structural changes associated with schizogony and gametogony in Eimeria tenella. Parasitology 59, 563–74.CrossRefGoogle ScholarPubMed
McLaren, D. J., & Paget, G. E., (1968). A fine structural study on the merozoites of Eimeria tenella with special reference to the conoid apparatus. Parasitology 58, 561–71.CrossRefGoogle Scholar
Ryley, J. F., & Wilson, R. G., (1971). Studies on the mode of action of the coccidiostat Robenidene. Zeitschrift für Parasitenkunde 37, 85–93.CrossRefGoogle ScholarPubMed
Scholtyseck, E., (1969). Electron microscope studies of the effect upon the host cell of various developmental stages of Eimeria tenella in the natural chicken host and in tissue cultures. Acda Veterinaria (Brno) 38, 153–6.Google Scholar
Scholtyseck, E., Gönnert, R., & Haberkorn, A., (1969). Die Feinstruktur der Makrogameten des Hühnercoccids Eimeria tenella. Zeitschrift für Parasitenkunde 33, 31–43.CrossRefGoogle Scholar
Scholtyseck, E., Rommel, A. S., & Heller, A., (1969). Licht und elektronen-mikroskopiche Untersuchungen zur bildung der oocysten hülle bei Eimeria (Eimeria perforans E. stiedae und E. tenella). Zeitschrift für Parasitenkunde 31, 289–98.CrossRefGoogle Scholar
Scholtyseck, E., & Strout, R. G., (1968). Feinstrukturentersuchungen üben die Nahrungsaufnahme bei Coccidien in Gewebekulturen (Eimeria tenella). Zeitschrift für Parasitenkunde 30, 291–300.CrossRefGoogle Scholar
Scholtyseck, E., Strout, R. G., & Haberkorn, A., (1969). Schizonten und Merozoiten von Eimeria tenella in Makrophagen. Zeitschrift für Parasitenkunde 32, 284–96.CrossRefGoogle Scholar
Senaud, J., & Černa, Z., (1969). ÉStude ultrastructural des merozoites et de la schizogenie des coccidies (Eimeria) Eimeria magna (Perard, 1925) de l'intestine des lapin et E. tenella (Railliet et Lucet, 1891) des coecum des poulets. Journal of Protozoology 16, 155–65.CrossRefGoogle Scholar