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Efficacy of two cyclooctadepsipeptides, PF1022A and emodepside, against anthelmintic-resistant nematodes in sheep and cattle

Published online by Cambridge University Press:  04 October 2004

G. VON SAMSON-HIMMELSTJERNA ,
A. HARDER ,
N. C. SANGSTER  and
G. C. COLES
G. VON SAMSON-HIMMELSTJERNA
Affiliation:
Institute for Parasitology, Hannover School of Veterinary Medicine, Bünteweg 17, D-30559 Hannover, Germany
A. HARDER
Affiliation:
Bayer AG, BHC-AH-RD/Para, Agricultural Centre Monheim, D-51368 Leverkusen, Germany
N. C. SANGSTER
Affiliation:
Faculty of Veterinary Science, University of Sydney, Sydney, NSW 2006, Australia
G. C. COLES
Affiliation:
Department of Clinical Veterinary Science, University of Bristol, Langford House, Bristol BS40 5 DU, UK
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Abstract

Resistance against the major currently available anthelmintics has reached a critical level in many small ruminant herds world-wide, and is increasingly becoming a problem in horses and cattle. Therefore, new products with different modes of action are urgently needed. Recently, such a new class of compounds, the anthelmintically active cyclooctadepsipeptides, was described. Here, the effects of cyclooctadepsipeptides on benzimidazole-, levamisole- and ivermectin-resistant populations of Haemonchus contortus in sheep as well as an ivermectin-resistant Cooperia oncophora population in cattle were studied. Experimentally infected sheep and cattle were used. Animals were treated orally, subcutaneously, or intravenously with cyclooctadepsipeptides. The anthelmintic effects were assessed by means of fecal egg count reductions and/or worm count reductions. Both, PF1022A and emodepside were found to be fully effective against these parasite populations. These findings confirm that this new class of compounds acts by a different mode of action compared to the above-mentioned anthelmintics.

Keywords

PF1022Aemodepsidecyclooctadepsipeptidenematodeanthelmintic resistance
Type
Research Article
Information
Parasitology , Volume 130 , Issue 3 , March 2005 , pp. 343 - 347
Copyright
2004 Cambridge University Press

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