Hostname: page-component-cd9895bd7-gvvz8 Total loading time: 0 Render date: 2025-01-06T00:42:20.558Z Has data issue: false hasContentIssue false
  • English
  • Français

Efficacy of two cyclooctadepsipeptides, PF1022A and emodepside, against anthelmintic-resistant nematodes in sheep and cattle

Published online by Cambridge University Press:  04 October 2004

G. VON SAMSON-HIMMELSTJERNA ,
A. HARDER ,
N. C. SANGSTER  and
G. C. COLES
G. VON SAMSON-HIMMELSTJERNA
Affiliation:
Institute for Parasitology, Hannover School of Veterinary Medicine, Bünteweg 17, D-30559 Hannover, Germany
A. HARDER
Affiliation:
Bayer AG, BHC-AH-RD/Para, Agricultural Centre Monheim, D-51368 Leverkusen, Germany
N. C. SANGSTER
Affiliation:
Faculty of Veterinary Science, University of Sydney, Sydney, NSW 2006, Australia
G. C. COLES
Affiliation:
Department of Clinical Veterinary Science, University of Bristol, Langford House, Bristol BS40 5 DU, UK
Get access Rights & Permissions [Opens in a new window]

Abstract

Resistance against the major currently available anthelmintics has reached a critical level in many small ruminant herds world-wide, and is increasingly becoming a problem in horses and cattle. Therefore, new products with different modes of action are urgently needed. Recently, such a new class of compounds, the anthelmintically active cyclooctadepsipeptides, was described. Here, the effects of cyclooctadepsipeptides on benzimidazole-, levamisole- and ivermectin-resistant populations of Haemonchus contortus in sheep as well as an ivermectin-resistant Cooperia oncophora population in cattle were studied. Experimentally infected sheep and cattle were used. Animals were treated orally, subcutaneously, or intravenously with cyclooctadepsipeptides. The anthelmintic effects were assessed by means of fecal egg count reductions and/or worm count reductions. Both, PF1022A and emodepside were found to be fully effective against these parasite populations. These findings confirm that this new class of compounds acts by a different mode of action compared to the above-mentioned anthelmintics.

Keywords

PF1022Aemodepsidecyclooctadepsipeptidenematodeanthelmintic resistance
Type
Research Article
Information
Parasitology , Volume 130 , Issue 3 , March 2005 , pp. 343 - 347
Copyright
2004 Cambridge University Press

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

BOERSEMA, J. H., EYSKER, M. & NAS, J. W. ( 2002). Apparent resistance of Parascaris equorum to macrocyclic lactones. Veterinary Record 150, 279–281.CrossRefGoogle Scholar
COLES, G. C. ( 2002). Cattle resistant to anthelmintics: why so few cases? Veterinary Research 33, 481–489.Google Scholar
FUKASHE, T., KOIKE, T., CHINONE, S., AKIHAMA, S., IAGAKE, H., TAKAGI, M., SHIMIZU, T., YAGUCHI, T., SASAKI, T. & OKADA, T. ( 1990). Anthelmintic effects of PF1022, a new cyclic depsipeptide, on the intestinal parasitic nematodes in dogs and cats. Proceedings of the 110th Meeting of the Japanese Society of Veterinary Science, 122 (Abstr.).Google Scholar
HARDER, A. ( 2002). Chemotherapeutic approaches to nematodes: current knowledge and outlook. Parasitology Research 88, 272–277.Google Scholar
HARDER, A. & SAMSON-HIMMELSTJERNA, G.VON ( 2002). Cyclooctadepsipeptides – a new class of anthelmintically active compounds. Parasitology Research 88, 481–488.CrossRefGoogle Scholar
MARTIN, R., HARDER, A., LONDERSHAUSEN, M. & JESCHKE, P. ( 1996). Anthelmintic actions of the cyclic depsipeptide PF1022A and electrophysiological effects on muscle cells of Ascaris suum. Pesticide Science 48, 343–349.3.0.CO;2-X>CrossRefGoogle Scholar
MEJIA, M. E., FERNANDEZ IGARTUA, B. M., SCHMIDT, E. E. & CABARET, J. ( 2003). Multispecies and multiple anthelmintic resistance on cattle nematodes in a farm in Argentina: the beginning of high resistance? Veterinary Research 34, 461–467.Google Scholar
SAEGER, B., SCHMITT-WREDE, H. P., DEHNHARDT, M., BENTEN, W. P., KRÜCKEN, J., HARDER, A., SAMSON-HIMMELSTJERNA, G.VON, WIEGAND, H. & WUNDERLICH, F. ( 2001). Latrophilin-like receptor from the parasite nematode Haemonchus contortus as target for the anthelmintic depsipeptide PF1022A. FASEB Journal 15, 1332–1334.CrossRefGoogle Scholar
SANGSTER, N. C. ( 2001). Managing parasiticide resistance. Veterinary Parasitology 98, 89–109.CrossRefGoogle Scholar
SANGSTER, N. C. & GILL, J. ( 1999). Pharmacology of anthelmintic resistance. Parasitology Today 15, 141–146.CrossRefGoogle Scholar
SAMSON-HIMMELSTJERNA, G.VON, HARDER, A., SCHNIEDER, T., KALBE, J. & MENCKE, N. ( 2000). In vivo activities of the new anthelmintic depsipeptide PF1022A. Parasitology Research 86, 194–199.CrossRefGoogle Scholar
SASAKI, T., TAKAGI, T., YAGUCHI, T., MIYADOH, S., OKADA, T. & KOYAMA, M. ( 1992). A new anthelmintic cyclodepsipeptide, PF1022A. Journal of Antibiotics 45, 692–697.CrossRefGoogle Scholar
SCHERKENBECK, J., JESCHKE, P. & HARDER, A. ( 2002). PF1022A and related cyclodepsipeptides – a novel class of anthelmintics. Current Topics in Medicinal Chemistry 2, 759–777.CrossRefGoogle Scholar
STAFFORD, K. & COLES, G. C. ( 1999). Nematode control practices and anthelmintic resistance in dairy calves in the south west of England. Veterinary Record 144, 659–661.CrossRefGoogle Scholar
TAGAKI, M., SASAKI, T., YAGUCHI, T., KODAMA, Y., OKADA, T., MIYADOH, S. & KOYAMA, M. ( 1991). On a new cyclic depsipeptide, PF1022 with anthelmintic effects. Nippon Nogeikagaku Kaishi 65, 326.Google Scholar
TERADA, M. ( 1992). Neuropharmacological mechanism of action of PF1022A, an antinematode anthelmintic with a new structure of cyclic depsipeptide, on Angiostrongylus cantonensis and isolated frog rectus. Japanese Journal of Parasitology 41, 108–117.Google Scholar
WALLER, P. J. ( 1997). Anthelmintic resistance. Veterinary Parasitology 72, 391–412.CrossRefGoogle Scholar
WETZEL, R. ( 1951). Verbesserte McMaster Kammer zum Auszählen von Wurmeiern. Tierärztliche Umschau 11, 209.Google Scholar
WILLSON, J., AMLIWALA, K., HARDER, A., HOLDEN-DYE, L. & WALKER, R. ( 2003). The effect of the anthelmintic emodepside at the neuromuscular junction of the parasitic nematode Ascaris suum. Parasitology 126, 79–86.CrossRefGoogle Scholar
WOOD, I. B., AMARAL, N. K., BAIRDEN, K., DUNCAN, J. L., KASSAI, T., MALONE, J. B., PANAKOVICH, J. A., REINECKE, R. K., SLOCOMBE, O., TAYLOR, S. M. & VERCRUYSSE, J. ( 1995). World Association for the Advancement of Veterinary Parasitology (W.A.A.V.P.) second edition of guidelines for evaluating the efficacy of anthelmintics in ruminants (bovine, ovine, caprine). Veterinary Parasitology 58, 181–213.Google Scholar