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Efficacy of the EG95 hydatid vaccine in a macropodid host, the tammar wallaby

Published online by Cambridge University Press:  06 February 2009

T. S. BARNES ,
L. A. HINDS ,
D. J. JENKINS ,
G. T. COLEMAN ,
A. L. COLEBROOK ,
C. T. KYNGDON ,
C. G. GAUCI  and
M. W. LIGHTOWLERS
T. S. BARNES*
Affiliation:
The University of Queensland, School of Veterinary Science, 4072, Australia
L. A. HINDS
Affiliation:
CSIRO Entomology, G.P.O. Box 1700, Canberra, ACT 2602, Australia
D. J. JENKINS
Affiliation:
Parasitech, 55 Carstensz Street, Griffith, ACT 2603 Australian Hydatid Control and Research Laboratory, School of Animal and Veterinary Sciences, Charles Sturt University, Locked Bag 588, Wagga Wagga, NSW 2678, Australia
G. T. COLEMAN
Affiliation:
The University of Queensland, School of Veterinary Science, 4072, Australia
A. L. COLEBROOK
Affiliation:
The University of Melbourne, Veterinary Clinical Centre, 250 Princes Highway, Werribee, Victoria 3030, Australia
C. T. KYNGDON
Affiliation:
The University of Melbourne, Veterinary Clinical Centre, 250 Princes Highway, Werribee, Victoria 3030, Australia
C. G. GAUCI
Affiliation:
The University of Melbourne, Veterinary Clinical Centre, 250 Princes Highway, Werribee, Victoria 3030, Australia
M. W. LIGHTOWLERS
Affiliation:
The University of Melbourne, Veterinary Clinical Centre, 250 Princes Highway, Werribee, Victoria 3030, Australia
*
*Corresponding author: The University of Queensland, School of Veterinary Science, Queensland, 4072, Australia. Tel: +61 7 3365 3023. Fax: +61 7 3365 1255. E-mail: [email protected]
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Summary

In Australia, macropodids are common intermediate hosts for the cestode Echinococcus granulosus, and sylvatic transmission is maintained via wild dogs. The parasite causes mortality in a number of macropodid species and the sylvatic cycle provides a source of infection to domestic livestock and humans. We determined the efficacy of the hydatid vaccine, EG95 in the tammar wallaby, Macropus eugenii, challenging either 1 or 9 months post-vaccination. EG95 provides similar protection to that seen in sheep (96–100%). Control tammars were significantly more likely to become infected (odds ratio 29·44; CI 4·13, 209·97; P=0·001) and to develop more cysts (count ratio 26·69; CI 5·83, 122·19; P<0·001). The vaccination may be beneficial if administered pre-release in captive breeding programmes for endangered macropodids. Further work to develop oral delivery methods may enable vaccine administration of wild animals and thereby a reduction in sylvatic transmission.

Keywords

Echinococcus granulosushydatidmarsupialmacropodidEG95vaccination
Type
Research Article
Information
Parasitology , Volume 136 , Issue 4 , April 2009 , pp. 461 - 468
Copyright
Copyright © 2009 Cambridge University Press

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