Hostname: page-component-586b7cd67f-tf8b9 Total loading time: 0 Render date: 2024-11-23T22:57:05.987Z Has data issue: false hasContentIssue false
  • English
  • Français

Efficacy of narasin against hepatic and intestinal coccidiosis in rabbits

Published online by Cambridge University Press:  08 November 2011

J. E. Peeters ,
Rita Geeroms ,
Odette Antoine ,
M. Mammerickx  and
P. Halen
J. E. Peeters
Affiliation:
Nationaal Instituut voor Diergeneeskundig Onderzoek, Groeselenberg, 99–1180 Brussel, Belgium
Get access Rights & Permissions [Opens in a new window]

Summary

The anticoccidial effect of narasin against Eimeria flavescens, E. intestinalis, E. magna, E. perforans and E. stiedai was tested in experimentally infected rabbits. The drug was highly effective in reducing oocyst output and in preventing clinical signs. Maximum activity as measured by oocyst discharge was achieved with feed levels from 12 to 24 p.p.m.; there was no influence on oocyst sporulation. Optimal weight gain and food consumption were obtained with levels between 8 and 12 p.p.m.; at higher levels there was an adverse effect on growth, food intake, relative liver and heart weights and on serum potassium and glucose.

Type
Research Article
Information
Parasitology , Volume 83 , Issue 2 , October 1981 , pp. 293 - 301
Copyright
Copyright © Cambridge University Press 1981

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Bombeke, A. & Okerman, F. (1973). L'influence de quelques anticoccidiens dans l'aliment composé sur la croissance et l'indice de consommation de lapins de boucherie. Compte Rendu du Vième Congrès International de Cuniculture, Section Nutrition, Como, 283–94.Google Scholar
Chappel, L. R. (1979). The site of action of the anticoccidial salinomycin (Coxistac). Journal of Parasitologu 65, 137–43.CrossRefGoogle ScholarPubMed
Coudert, P. (1976). La coccidiose hépatique: son agent, ses effets pathogènes. ler Congrès International Cunicole, Dijon, Communication no. 38.Google Scholar
Coudert, P. (1978). Les coccidies du lapin: essais de traitements. Cuniculture 5, 119–22.Google Scholar
Danforth, H. D., Ruff, M. D., Reid, W. M. & Miller, R. L. (1977a). Anticoccidial activity of salinomycin in battery raised broiler chickens. Poultry Science 56, 926–32.CrossRefGoogle ScholarPubMed
Danforth, H. D., Ruff, M. D., Reid, W. M. & Johnson, Y. (1977b). Anticoccidial activity of salinomycin in floor-pen experiments with broilers. Poultry Science 56, 933–8.CrossRefGoogle ScholarPubMed
Fitzgerald, P. R. (1972). Efficacy of monensin or amprolium in the prevention of hepatic coccidiosis in rabbits. Journal of Protozoology 19, 332–4.CrossRefGoogle ScholarPubMed
Fitzgerald, P. R. (1976). Efficacy of antibiotics A204 sodium, A28695A and A204 np against coccidia of rabbits. Journal of Protozoology 23, 150–4.CrossRefGoogle ScholarPubMed
Gwyther, M. J. (1976). Efficacy of monensin and sulfaquinoxaline against the coccidium Eimeria stiedai in rabbits. Master's thesis, Clemson University.Google Scholar
Joyner, L. P. & Norton, C. C. (1977). The anticoccidial effects of amprolium, dinitolmide and monensin against Eimeria maxima, E. brunetti and E. acervulina with particular reference to oocyst sporulation. Parasitology 55, 155–64.CrossRefGoogle Scholar
Macphbrson, I. (1978). Coccidiosis in broilers and turkeys. In Avian Coccidiosis, (ed. Long, P. L., Boorman, K. N. and Freeman, B. M.), pp. 465–94. Edinburgh: British Poultry Science Ltd.Google Scholar
MAFF. (1977). Manual of Veterinary Parasitological Laboratory Technigues. Technical Bulletin no. 18. Ministry of Agriculture, Fisheries and Food.Google Scholar
Matsuoka, T. (1976). Evaluation of monensin toxicity in the horse. Journal of the American Veterinary Medical Association 169, 1098–100.Google ScholarPubMed
McDougald, L. R. & Galloway, R. B. (1976). Anticoccidial drugs: effects on infectivity and survival intracellularly of Eimeria sporozoites. Experimental Parasitology 40, 314–19.CrossRefGoogle Scholar
Meyers, D. B., Todd, G. C & Gibson, W. R. (1971). Evidence of depletion of intracellular potassium by A204 in the rat. Antimicrobial Agents and Chemotherapy 1970, 91–4.Google Scholar
Okerman, F. & Moermans, R. J. (1980). De invloed van het coccidiostaticum salinomycine als additief in samengesteld voeder op de produktieresultaten van slachtkonijnen. Land- bouwtijdschrift 33, 1295–306.Google Scholar
Peeters, J. E. & Halen, P. (1980). Robenidine treatment of rabbits naturally infected with coccidia. Laboratory Animals 14, 53–4.CrossRefGoogle ScholarPubMed
Pressman, B. C. (1976). Biological applications of ionophores. Annual Review of Biochemistry 45, 501–30.CrossRefGoogle ScholarPubMed
Ruff, M. D., Reid, W. M., Johnson, J. K. & Anderson, W. A. (1979). Anticoccidial activity of narasin in battery raised broiler chickens. Poultry Science 58, 298–303.CrossRefGoogle ScholarPubMed
Sambeth, W. (1980). Salinomycin, ein neues Coccidiostatikum für Kaninchen. Proceedings of the 2nd World's Rabbit Congress, Barcelona, vol. 2, pp. 293–6.Google Scholar
Shumard, R. F. & Callender, M. E. (1968). Monensin, a new biologically active compound. Anticoccidial activity. Antimicrobial Agents and Chemotherapy 1967, 369–77.Google Scholar
Todd, G. C., Meyers, D. B., Pierce, E. C. & Worth, H. M. (1971). Acute reversible myopathy produced by compound A204. Antimicrobial Agents and Chemotherapy 1970, 361–5.Google Scholar
Weppelman, R. M., Olson, G., Smith, D. A., Tamas, T. & Van Iderstine, A. (1977). Comparison of anticoccidial efficacy, resistance and tolerance of narasin, monensin and lasalocid in chicken battery trials. Poultry Science 56, 1550–9.CrossRefGoogle ScholarPubMed
Wong, D. T., Berg, D. H., Hamill, R. H. & Wilkinson, K. R. (1977). Ionophorous properties of narasin, a new polyether monocarboxylic acid antibiotic in rat liver mitochondria. Biochemical Pharmacology 26, 1373–6.CrossRefGoogle ScholarPubMed
Wong, D. T., Horng, J. S., Hamill, R. L. & Lardy, H. A. (1971). Effect of a new monocarboxylic acid antibiotic, A204, on the monovalent cation permeability of rat liver mitochondria. Biochemical Pharmacology 20, 3169–77.CrossRefGoogle ScholarPubMed
Worth, H.M., Meyers, D. B., Gibson, W. R. & Todd, G. C. (1971). Acute and subacute toxicity of A204. Antimicrobial Agents and Chemotherapy, 1970, 357–60.Google Scholar