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Effects of cyclophosphamide and dexamethasone on mast cell populations in Hymenolepis microstoma-infected mice

Published online by Cambridge University Press:  06 April 2009

M. Novak ,
L. G. Buchannan  and
H. Howlader
M. Novak
Affiliation:
Department of BiologyUniversity of Winnipeg, Winnipeg, Manitoba, Canada R3B 2E9
L. G. Buchannan
Affiliation:
Department of BiologyUniversity of Winnipeg, Winnipeg, Manitoba, Canada R3B 2E9
H. Howlader
Affiliation:
Department of Statistics, University of Winnipeg, Winnipeg, Manitoba, Canada R3B 2E9
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Summary

Antineoplastic cyclophosphamide (CY) significantly reduced the survival and the weight of Hymenolepis microstoma in mice. Corticosteroid dexamethasone (DEX), on the other hand, did not influence the worm survival and the worms in DEX-treated mice became significantly heavier. Both immunosuppressants abolished H. microstoma-induced bile duct hypertrophy and submucous enteritis and lowered the number of mast cells (MC) in these regions. CY appeared to be more effective in depleting the bile duct MC whereas DEX seemed to affect more the duodenal MC population.

Keywords

Hymenolepis microstomamast cellscyclophosphamidedexamethasone
Type
Research Article
Information
Parasitology , Volume 100 , Issue 2 , April 1990 , pp. 337 - 343
Copyright
Copyright © Cambridge University Press 1990

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References

Andreassen, J., Hindsbo, O. & Ruitenberg, E. J. (1978). Hymenolepis diminuta infections in congenitally athymic (nude) mice: worm kinetics and intestinal histopathology. Immunology 34, 105–13Google ScholarPubMed
Befus, A. D. & Bienenstock, J. (1979). Immunologically mediated intestinal mastocytosis in Nippostrongylus brasiliensis infected rats. Immunology 38, 95101Google Scholar
Befus, A. D., Johnston, N. & Bienenstock, J. (1979). Nippostrongylus brasiliensis: mast cells and histamine levels in tissues of infected and normal rats. Experimental Parasitology 48, 18.CrossRefGoogle ScholarPubMed
Befus, A. D., Pearce, F. L., Gauldie, J., H.orsewood, P. & Bienenstock, J. (1982). Mucosal mast cells. I.Isolation and functional characteristics of rat intestinal mast cells. Journal of Immunology 128, 2475–80.Google Scholar
Calabresi, P. & Parks, R. E. (1971). Chemotherapy of neoplastic diseases. In Pharmacological Basis ofTherapeutics, 4th edn (ed. Goodwan, L. S. & Gilman, A.), pp. 1345–93. London and Toronto: The Macmillan Co.Google Scholar
Evans, R. (1983). Combination therapy using cyclophosphamide and tumor-sensitized lymphocytes: a possible mechanism of action. Journal of Immunology 130, 2511–20.CrossRefGoogle ScholarPubMed
Fauci, A.S. (1979). Immunosuppressive and antiinflammatory effects of glucocorticoids. In Monographs on Endocrinology (ed. Baxter, J. D. & Rousseau, G. G.), pp.449–65. New York: SpringerVerlag.Google Scholar
Hinz, E. (1964). Chemotherapeutische Untersuchungen mit Endoxan an der experimentellen Finneninfection der weissen Maus. Zeitschrift für Tropenmedizin und Parasitologie 15, 332–6.Google Scholar
Jones, T. C., Alkan, S. & Erb, P. (1987). Murine spleen and lymph node cellular composition and function during cyclophosphamide and splenectomy induced resistance to Toxoplasma gondii. Parasite Immunology 9, 117– 31.Google Scholar
Lee, T. D. G., Shanahan, F., Miller, H. R. P., Bienenstock, J. & Befus, A. D. (1985). Intestinal mucosal mast cells: isolation from rat lamina propria and purification using unit gravity velocity sedimentation. Immunology 55, 721–8.Google Scholar
Lindsay, M. C. & Williams, J. F. (1985). Hepatic mast cells in rats infected with Taenia taeniaeformis. International Journal for Parasitology 15, 203–9.Google Scholar
Lubinsky, C. & Galaugher, W. (1967). Inhibition of the growth of Echinococcus multilocularis cysts by cyclophosphamide. Canadian Journal of Zoology 45, 1302–3.Google Scholar
Miller, H. R. P. (1984). The protective mucosal response against gastrointestinal nematodes in ruminants and laboratory animals. Veterinary Immunology and Immunopathology 6, 167–259.CrossRefGoogle ScholarPubMed
Miller, H. R. P. & Huntley, J. F. (1982). Intestinal mucus and protection against Nippostrongylus brasiliensis, the effect of corticosteroids in immune rats. Molecular and Biochemical Parasitology (Suppl.) 4.Google Scholar
Miller, H. R. P. & Jarrett, W. F. J. (1971). Immune reactions in mucous membranes. I. Intestinal mast cell response during helminth expulsion in the rat. Immunology 20, 277–86.Google ScholarPubMed
Miller, H. R. P. & Nawa, Y. (1979). Nippostrongylus brasiliensis: intestinal goblet cell response in adoptively immunized rats. Experimental Parasitology 47, 81–90.Google Scholar
Moqbel, R., King, S. Y., Macdonald, A. J., Miller, H. R. P., Cromwell, O., Shaw, R. J. & Kay, A. B. (1986). Enteral and systemic release of leucotrienes during anaphylaxis of Nippostrongylus brasiliensis-primed rats. Journal of Immunology 137, 296–301.CrossRefGoogle Scholar
Moss, G. D. (1972). The effect of cortisone acetate treatment on the growth of Hymenolepis microstoma in mice. Parasitology 64, 311–20.CrossRefGoogle ScholarPubMed
North, R. J. (1982). Cyclophosphamide-facilitated adoptive immunotherapy of an established tumor depends on elimination of tumor-induced suppressor T cells. Journal of Experimental Medicine 155, 1063–75.CrossRefGoogle ScholarPubMed
Novak, M. & Nombrado, S. (1988). Mast cell responses to Hymenolepis microstoma infection in mice. Journal ofParasitology 74, 81–8.Google Scholar
Novak, M. & Nombrado, S. (1989). An improved method for staining mouse mast cells. Canadian Journal of Zoology 67, 226–7.Google Scholar
Ott, L. (1984). An Introduction to Statistical Methods and Data Analysis, 2nd Edn., pp. 373–6. Duxbury Press.Google Scholar
Turk, J. L. & Poulter, L. W. (1972). Selective depletion of lymphoid tissue by cyclophosphamide. Clinical and Experimental Immunology 10, 285–96.Google ScholarPubMed
Woodbury, R. G., Miller, H. R. P., Huntley, J. F., Newlands, G. F. J., Palliser, A. C. & Wakelin, D. (1984). Mucosal mast cells are functionally active during spontaneous expulsion of intestinal nematode infections in rats. Nature, London 312, 450–2.Google Scholar