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Effect of selection pressure for thiabendazole resistance on fitness of Haemonchus contortus in sheep

Published online by Cambridge University Press:  06 April 2009

N. Maingi ,
M. E. Scott  and
R. K. Prichard
N. Maingi
Affiliation:
Institute of Parasitotogy, Macdonald College of McGill University, 21 111 Lakeshore Road, Ste-Anne de Bellevue, Quebec H9X 1CO, Canada
M. E. Scott
Affiliation:
Institute of Parasitotogy, Macdonald College of McGill University, 21 111 Lakeshore Road, Ste-Anne de Bellevue, Quebec H9X 1CO, Canada
R. K. Prichard
Affiliation:
Institute of Parasitotogy, Macdonald College of McGill University, 21 111 Lakeshore Road, Ste-Anne de Bellevue, Quebec H9X 1CO, Canada
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Summary

A Strain ofHaemonchus contortusshowing moderate levels of resistance to thiabendazole (TBZ) (egg hatch assay LC50 2.1 μM) was subjected, in alternating sequence, to 5 in vitro and 4 in vivo selections with TBZ. This resulted in a significant increase in resistance (egg hatch assay LC50 2.8 μM). The isolates obtained after each combined in vitro and in vivo selection were compared in terms of egg hatch assay, establishment, net egg output, per capita egg output and degree of pathology caused in infected hosts. The increase in resistance was accompanied by a significant increase in larval establishment sheep (22 %) and was associated with more severe pathology, higher egg count and worm recovery 3 months post- infection.

Keywords

thaibendazole resistanceHaemonchus contortusestablishmentegg productionpathogenesisfitness selection
Type
Research Article
Information
Parasitology , Volume 100 , Issue 2 , April 1990 , pp. 327 - 335
Copyright
Copyright © Cambridge University Press 1990

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