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The effect of colostrum on pigs pre-natally or post-natally exposed to Schistosoma japonicum

Published online by Cambridge University Press:  05 October 2004

M. E. TECHAU ,
M. V. JOHANSEN ,
P. LIND  and
N. ORNBJERG
M. E. TECHAU
Affiliation:
Danish Bilharziasis Laboratory, Jaegersborg Allé 1D, DK-2920 Charlottenlund, Denmark Danish Centre for Experimental Parasitology, Dyrlaegevej 100, 1870 Frederiksberg C, Denmark
M. V. JOHANSEN
Affiliation:
Danish Bilharziasis Laboratory, Jaegersborg Allé 1D, DK-2920 Charlottenlund, Denmark
P. LIND
Affiliation:
Department of Immunology and Biochemistry, Danish Veterinary Institute 27 Bülowsvej, DK-1790 Copenhagen V, Denmark
N. ORNBJERG
Affiliation:
Danish Bilharziasis Laboratory, Jaegersborg Allé 1D, DK-2920 Charlottenlund, Denmark
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Abstract

Pre-natal infection of Schistosoma japonicum in pigs may prove to be a useful model in shedding light on human pre-natal schistosomiasis. This study describes the effects of immune colostrum on worm burdens, tissue egg counts, liver pathology and crude worm or egg antigen-specific IgG and IgA responses, in groups of pigs pre-natally, pre-natally+post-natally or post-natally exposed to S. japonicum. Results suggest that pre-natal exposure and immune colostrum did not affect the establishment of a post-natal challenge infection. However, immune colostrum seemed to increase the levels of septal fibrosis in pre-natally exposed pigs. These findings indicate that further investigations will prove valuable, elucidating the influence of the parasitological and immunological status of the sow, on pre-natally exposed pigs, and on the ability of these pigs to develop resistance against S. japonicum later in life.

Keywords

Schistosoma japonicumpre-natal exposurecolostrumIgGIgA
Type
Research Article
Information
Parasitology , Volume 129 , Issue 5 , November 2004 , pp. 597 - 604
Copyright
© 2004 Cambridge University Press

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