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Duration of invasiveness of Entamoeba histolytica maintained in vitro

Published online by Cambridge University Press:  06 April 2009

Patricia Vincent  and
R. A. Neal
Patricia Vincent
Affiliation:
Wellcome Laboratories of Tropical Medicine, London, N. W. 1
R. A. Neal
Affiliation:
Wellcome Laboratories of Tropical Medicine, London, N. W. 1
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Extract

The infectivity and invasiveness of a single strain of Entamoeba histolytica to young rats has been studied over a period of 12 years. The virulence was slowly lost over a period of months or years of cultivation in vitro. After four to six liver passages, virulence was again established and again declined in culture. This was repeated on three occasions. Each time the strain lost virulence, the capacity to invade the mucosa was lost before the amoebae became non-infective to young rats. The duration of experimentally acquired virulence was progressively reduced after each succeeding series of liver passages.

Type
Research Article
Information
Parasitology , Volume 50 , Issue 3-4 , November 1960 , pp. 449 - 452
Copyright
Copyright © Cambridge University Press 1960

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References

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