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Different levels of acquired immunity to Schistosoma mansoni in two strains of hamster

Published online by Cambridge University Press:  06 April 2009

M. A. Smith  and
J. A. Clegg
M. A. Smith
Affiliation:
Department of Zoology, Imperial College of Science and Technology, London, SW7 2BB
J. A. Clegg
Affiliation:
National Institute for Medical Research, London, NW7 1AA
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Summary

A primary infection with Schistosoma mansoni, of 5 or more weeks duration, stimulated a high level of resistance to a challenge infection in the WO outbred strain of golden hamster. In sharp contrast, the LGN strain showed no statistically significant immunity to reinfection in most experiments and where detected the level of resistance was only about half that observed in the WO strain. Immunity to reinfection was assayed with the lung recovery method which assesses resistance a few days after challenge and with the conventional perfusion assay which measures immunity 6 weeks after challenge. Wide differences in the immune response to S. mansoni in different strains of the same host species have not been reported previously.

Type
Research Article
Information
Parasitology , Volume 73 , Issue 1 , August 1976 , pp. 47 - 52
Copyright
Copyright © Cambridge University Press 1976

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References

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