Hostname: page-component-586b7cd67f-r5fsc Total loading time: 0 Render date: 2024-11-24T02:03:53.284Z Has data issue: false hasContentIssue false
  • English
  • Français

Development of patent Ascaris suum infections in pigs following intravenous administration of larvae hatched in vitro

Published online by Cambridge University Press:  01 November 1999

G. JUNGERSEN ,
H.-P. FAGERHOLM ,
P. NANSEN  and
L. ERIKSEN
G. JUNGERSEN
Affiliation:
Danish Veterinary Laboratory Bülowsvej 27, 1790 Cophenhagen V, Denmark
H.-P. FAGERHOLM
Affiliation:
Institute of Parasitology, Department of Biology, Åbo Akademi University, BioCity, Artillerig 6, 20520 Åbo, Finland
P. NANSEN
Affiliation:
Danish Centre for Experimental Parasitology, Royal Veterinary and Agricultural University, Bülowsvej 17, 1870 Frederiksberg C, Copenhagen, Denmark
L. ERIKSEN
Affiliation:
Department of Clinical Studies, Large Animal Medicine, Royal Veterinary and Agricultural University, Bülowsvej 17, 1870 Frederiksberg C, Copenhagen, Denmark
Get access Rights & Permissions [Opens in a new window]

Abstract

The normal tissue migration of Ascaris suum in the pig host involves larval development in the liver accompanied by considerable pathological changes. The vast majority of larvae that reach the small intestine are later expelled by unknown mechanisms. We show that when migration through the liver is bypassed by inoculation of pigs with an intravenous dose of larvae hatched in vitro, the larvae not only complete migration and return to the small intestine, but they also seem to have a greater chance of survival to adulthood. This technique offers new possibilities for studies on specific lung involvement in protective immunity, provides valuable information for the understanding of self cure by larval expulsion, and adds to our understanding of the evolution of migration of Ascaris larvae in tissues.

Keywords

Ascaris suumintravenous inoculationsexperimental infectionsfixation of larvae
Type
Research Article
Information
Parasitology , Volume 119 , Issue 5 , November 1999 , pp. 503 - 508
Copyright
1999 Cambridge University Press

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)