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Development of irreversible lesions in the brain, heart and kidney following acute and chronic murine malaria infection

Published online by Cambridge University Press:  16 October 2009

P. N. VUONG ,
F. RICHARD ,
G. SNOUNOU ,
F. COQUELIN ,
L. RÉNIA ,
F. GONNET ,
A. G. CHABAUD  and
I. LANDAU
P. N. VUONG
Affiliation:
Unité d'Anatomie et de Cytologie Pathologiques, Hôpital Saint Michel, 33 Rue Olivier de Serre, Paris 75015, France
F. RICHARD
Affiliation:
Laboratoire de Biologie Parasitaire et Laboratoire de Protozoologie et Parasitologie Comparée (EPHE), Muséum National d'Histoire Naturelle, 61 Rue Buffon, 75231 Paris Cedex 05, France
G. SNOUNOU
Affiliation:
Department of Infection and Tropical Medicine, Imperial College School of Medicine, Northwick Park Hospital, Harrow, Middlesex HA1 3UJ, UK
F. COQUELIN
Affiliation:
Laboratoire de Biologie Parasitaire et Laboratoire de Protozoologie et Parasitologie Comparée (EPHE), Muséum National d'Histoire Naturelle, 61 Rue Buffon, 75231 Paris Cedex 05, France
L. RÉNIA
Affiliation:
U 445 INSERM, Institut Cochin de Génétique Moléculaire, Hôpital Cochin, Bâtiment Gustave Roussy, 27 Rue du Faubourg Saint Jacques, Paris 75014, France
F. GONNET
Affiliation:
Laboratoire de Biologie Parasitaire et Laboratoire de Protozoologie et Parasitologie Comparée (EPHE), Muséum National d'Histoire Naturelle, 61 Rue Buffon, 75231 Paris Cedex 05, France
A. G. CHABAUD
Affiliation:
Laboratoire de Biologie Parasitaire et Laboratoire de Protozoologie et Parasitologie Comparée (EPHE), Muséum National d'Histoire Naturelle, 61 Rue Buffon, 75231 Paris Cedex 05, France
I. LANDAU
Affiliation:
Laboratoire de Biologie Parasitaire et Laboratoire de Protozoologie et Parasitologie Comparée (EPHE), Muséum National d'Histoire Naturelle, 61 Rue Buffon, 75231 Paris Cedex 05, France
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Abstract

Irreversible pathological lesions were noted in the organs of mice infected with 1 of 3 rodent malaria species: Plasmodium chabaudi chabaudi, P. vinckei petteri and P. yoelii nigeriensis at different times during the course of the primary parasitaemia and long after microscopical clearance of the parasites. Moreover, similar lesions were also obtained when parasite levels were kept below 1%by subcurative drug treatment. The frequency and severity of the lesions correlated with the duration of the infection. Accumulation of tissue damage during chronic low-grade malaria infections has implications for the design of control measures.

Keywords

drug treatmenthistologypathologyPlasmodium chabaudi chabaudiPlasmodium vinckei petteriPlasmodium yoelii nigeriensis
Type
Research Article
Information
Parasitology , Volume 119 , Issue 6 , December 1999 , pp. 543 - 553
Copyright
© 1999 Cambridge University Press

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