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Cystic echinococcosis: analysis of the serological profile related to the risk factors in individuals without ultrasound liver changes living in an endemic area of Tacuarembó, Uruguay

Published online by Cambridge University Press:  02 November 2004

A. HERNÁNDEZ ,
G. CARDOZO ,
S. DEMATTEIS ,
A. BAZ ,
N. TRIAS ,
H. NUÑEZ ,
A. BARRAGUÉ ,
L. LÓPEZ ,
J. FUENTES  and
O. LÓPEZ
...Show all authors
A. HERNÁNDEZ
Affiliation:
Cátedra de Inmunología, Facultad de Química-Facultad de Ciencias, Instituto de Higiene, Avda. A. Navarro 3051, Montevideo 11600, Uruguay
G. CARDOZO
Affiliation:
Cátedra de Inmunología, Facultad de Química-Facultad de Ciencias, Instituto de Higiene, Avda. A. Navarro 3051, Montevideo 11600, Uruguay
S. DEMATTEIS
Affiliation:
Cátedra de Inmunología, Facultad de Química-Facultad de Ciencias, Instituto de Higiene, Avda. A. Navarro 3051, Montevideo 11600, Uruguay
A. BAZ
Affiliation:
Cátedra de Inmunología, Facultad de Química-Facultad de Ciencias, Instituto de Higiene, Avda. A. Navarro 3051, Montevideo 11600, Uruguay
N. TRIAS
Affiliation:
Cátedra de Inmunología, Facultad de Química-Facultad de Ciencias, Instituto de Higiene, Avda. A. Navarro 3051, Montevideo 11600, Uruguay
H. NUÑEZ
Affiliation:
Hospital Regional, deTacuarembó, Treinta y Tres 444, Tacuarembó, Uruguay
A. BARRAGUÉ
Affiliation:
Hospital Regional, deTacuarembó, Treinta y Tres 444, Tacuarembó, Uruguay
L. LÓPEZ
Affiliation:
Hospital Regional, deTacuarembó, Treinta y Tres 444, Tacuarembó, Uruguay
J. FUENTES
Affiliation:
Cátedra de Matemáticas, Facultad de Química, Avda. General Flores 2124, Montevideo 11800, Uruguay
O. LÓPEZ
Affiliation:
Hospital Regional, deTacuarembó, Treinta y Tres 444, Tacuarembó, Uruguay
C. FERREIRA
Affiliation:
Hospital Regional, deTacuarembó, Treinta y Tres 444, Tacuarembó, Uruguay
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Abstract

Cystic echinococcosis (CE) is a high prevalence zoonosis among the rural population of Tacuarembó (Uruguay). The correlation between serological data and the incidence of risk factors was studied in a survey carried out in 1998 among rural communities where 480 individuals were examined by means of abdominal sonography (local prevalence=0·8%). Serum samples (305) were analysed by ELISA to determine specific IgG against crude antigens from Echinococcus granulosus. A total of 27 individuals exhibiting no detectable changes in abdominal sonographic examination were found to be seropositive (‘ultrasound normal group’). Of these individuals 9 were seroreactive against purified antigen B. A significant degree of correlation was found between seroreactivity and the incidence of some risk factors (CE antecedent in the family, P<0·005 and use of rural water, P<0·0001) among this group. Follow-up of individuals of the ‘ultrasound normal group’ was carried out after 2 years to evaluate the implications of this serological reactivity. No predictive value for cyst development was assessed with complementary image study; in contrast transient antibodies were observed with both crude and purified antigen as approximately 60% of individuals became negative when re-sampled.

Keywords

cystic echinococcosis (CE)Echinococcus granulosusrisk of exposureserological testsabdominal ultrasound
Type
Research Article
Information
Parasitology , Volume 130 , Issue 4 , April 2005 , pp. 455 - 460
Copyright
2004 Cambridge University Press

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