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Cryptosporidium infections: molecular advances

Published online by Cambridge University Press:  28 March 2014

MATTHIAS LENDNER  and
ARWID DAUGSCHIES
MATTHIAS LENDNER*
Affiliation:
Institute for Parasitology, An den Tierkliniken 35, 04103 Leipzig, Germany
ARWID DAUGSCHIES
Affiliation:
Institute for Parasitology, An den Tierkliniken 35, 04103 Leipzig, Germany
*
* Corresponding author: Matthias Lendner, Institut für Parasitologie, An den Tierkliniken 35, 04103 Leipzig, Germany. E-mail: [email protected]
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Summary

Cryptosporidium host cell interaction remains fairly obscure compared with other apicomplexans such as Plasmodium or Toxoplasma. The reason for this is probably the inability of this parasite to complete its life cycle in vitro and the lack of a system to genetically modify Cryptosporidium. However, there is a substantial set of data about the molecules involved in attachment and invasion and about the host cell pathways involved in actin arrangement that are altered by the parasite. Here we summarize the recent advances in research on host cell infection regarding the excystation process, attachment and invasion, survival in the cell, egress and the available data on omics.

Keywords

CryptosporidiumApicomplexahost-parasite interactionattachmentinvasionegressmucinactinomics
Type
Special Issue Article
Information
Parasitology , Volume 141 , Special Issue 11: ApiCOWplexa 2013 – 2nd International Meeting on Apicomplexan Parasites in Farm Animals , September 2014 , pp. 1511 - 1532
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Copyright © Cambridge University Press 2014 

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References

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