Hostname: page-component-cd9895bd7-fscjk Total loading time: 0 Render date: 2024-12-26T16:09:14.919Z Has data issue: false hasContentIssue false
  • English
  • Français

Comparison of chromosome and isoenzyme polymorphism in geographical populations of Leishmania (Viannia) peruviana

Published online by Cambridge University Press:  01 December 1998

J. C. DUJARDIN ,
A. L. BAÑULS ,
J. P. DUJARDIN ,
J. AREVALO ,
M. TIBAYRENC  and
D. LE RAY
J. C. DUJARDIN
Affiliation:
Laboratory of Protozoology, Instituut voor Tropische Geneeskunde ‘Prince Leopold’, Nationalestraat 155, B-2000 Antwerpen, Belgium
A. L. BAÑULS
Affiliation:
Centre d'Etudes sur le Polymorphisme des Microorganismes, UMR CNRS/ORSTOM 9926, ORSTOM, BP5045, F-34032 Montpellier, France
J. P. DUJARDIN
Affiliation:
Centre d'Etudes sur le Polymorphisme des Microorganismes, UMR CNRS/ORSTOM 9926, ORSTOM, BP5045, F-34032 Montpellier, France
J. AREVALO
Affiliation:
Instituto de Medicina Tropical ‘Alexander von Humboldt’, Universidad Peruana Cayetano Heredia, AP5045, Lima, Peru
M. TIBAYRENC
Affiliation:
Centre d'Etudes sur le Polymorphisme des Microorganismes, UMR CNRS/ORSTOM 9926, ORSTOM, BP5045, F-34032 Montpellier, France
D. LE RAY
Affiliation:
Laboratory of Protozoology, Instituut voor Tropische Geneeskunde ‘Prince Leopold’, Nationalestraat 155, B-2000 Antwerpen, Belgium
Get access Rights & Permissions [Opens in a new window]

Abstract

Five chromosomes and 17 isoenzyme loci were analysed in 4 allopatric populations of Leishmania (Viannia) peruviana, and molecular distances calculated with 2 estimators, Chromosomal Size Difference Index and Jaccard Distance. Chromosome and isoenzyme data were in overall concordance: 13/30 isolates clustered similarly on the dendrograms constructed from the different estimators, and a significant correlation (P<0·001) was observed between the molecular distances calculated from the two sets of characters. This indicates an evolutionary association between chromosomal size polymorphism and isoenzymes. Chromosomes have a faster molecular clock than isoenzymes; twice as many genotypes were identified by chromosome analysis and significant size differences (for a total of up to 500 kb for 5 chromosomes together) were observed within a given zymodeme. Chromosomes most likely represent better indicators of genetic drift than isoenzymes, as suggested by the higher correlation between both estimators of chromosomal size-polymorphism and eco-geography. Some chromosomes might present an adaptive response to environmental variation.

Keywords

Leishmania (Viannia) peruvianakaryotypeisoenzymesdriftselection
Type
Research Article
Information
Parasitology , Volume 117 , Issue 6 , December 1998 , pp. 547 - 554
Copyright
1998 Cambridge University Press

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)