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A comparative study of susceptibility of inbred and outbred mouse strains compared with hamsters to infection with New World cutaneous leishmaniases

Published online by Cambridge University Press:  06 April 2009

R. A. Neal  and
C. Hale
R. A. Neal
Affiliation:
Wellcome Research Laboratories, Beckenham, Kent BR3 3BS
C. Hale
Affiliation:
Wellcome Research Laboratories, Beckenham, Kent BR3 3BS
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Summary

One stock of each of Leishmania mexicana mexicana and L. m. amazonesis together with two stocks of L. braziliensis panamensis and L. b. braziliensis were tested for infectivity in inbred mouse strains Balb/c and CBA/H. The infectivity was compared with hamsters and the outbred CD1 mice. Balb/c mice were more susceptible than hamsters to L. mexicaba and L. braziliensis panamensis. Balb/c mice were not susceptible to L. b. braziliensis. CBA/H mice showed a low susceptibility to infection while CD1 mice showed an intermediate response

Type
Research Article
Information
Parasitology , Volume 87 , Issue 1 , August 1983 , pp. 7 - 13
Copyright
Copyright © Cambridge University Press 1983

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References

REFERENCES

Behin, R., Mauel, J. & Sordat, B. (1979). Leishmania tropica: pathogenicity and in vitro macrophage function in strains of inbred mice. Experimental Parasitology 48, 81–91.CrossRefGoogle ScholarPubMed
Handman, E., Ceredig, R. & Mitchell, G. F. (1979). Murine cutaneous leishmaniasis: disease patterns in intact and nude mice of various genotypes and examination of some differences between normal and infected macrophages. Australian Journal of Experimental Biology and Medical Science 57, 9–29.CrossRefGoogle ScholarPubMed
Howard, J. G., Hale, C. & Chan-Liew, W. L. (1980 a). Immunological regulation of experimental cutaneous leishmaniasis. I. Immunogenetic aspects of susceptibility of Leishmania tropica in mice. Parasite Immunology 2, 303–14.CrossRefGoogle ScholarPubMed
Howard, J. G., Hale, C. & Liew, F. Y. (1980 b). Immunological regulation of experimental cutaneous leishmaniasis. II. Nature and significance of specific suppression of cell-mediated immunity in mice highly susceptible to Leishmania tropica. Journal of Experimental Medicine 152, 594–607.CrossRefGoogle Scholar
Kellina, O. I. (1973). [On the difference in susceptibility of inbred mice of different strains to Leishmania tropica major.] Medical Parasitology and Parasitic Diseases 42, 279–85.Google Scholar
McKinney, L. A. & Hendricks, L. D. (1980). Experimental infection of Mystromys albicaudatus with Leishmania braziliensis: pathology. American Journal of Tropical Medicine and Hygiene 29, 753–60.CrossRefGoogle ScholarPubMed
Neal, R. A. (1964). Chemotherapy of cutaneous leishmaniasis: Leishmania tropica infections in mice. Annals of Tropical Medicine and Parasitology 58, 420–30.CrossRefGoogle ScholarPubMed
Neal, R. A. (1972). Effect of dihydrofolate reductase inhibitors on experimental cutaneous leishmaniasis, with especial emphasis on Leishmania isolates from Latin-America. Revista do Instituo de Medicina Tropical de São Paulo 14, 341–51.Google ScholarPubMed
Perez, H., Labrador, F. & Torrealba, J. W. (1979). Variations in the response of five strains of mice to Leishmania mexicana. International Journal for Parasitology 9, 27–31.CrossRefGoogle ScholarPubMed
Wilson, H. R., Dieckmann, B. S. & Childs, G. E. (1979). Leishmania braziliensis and Leishmania mexicana: experimental cutaneous infections in golden hamsters. Experimental Parasitology 47, 270–83.CrossRefGoogle ScholarPubMed