Hostname: page-component-cd9895bd7-mkpzs Total loading time: 0 Render date: 2024-12-27T12:36:21.193Z Has data issue: false hasContentIssue false
  • English
  • Français

Commercialisation of a recombinant vaccine against Boophilus microplus

Published online by Cambridge University Press:  06 April 2009

P. Willadsen ,
P. Bird ,
G. S. Cobon  and
J. Hungerford
P. Willadsen
Affiliation:
CSIRO Division of Tropical Animal Production, Meiers Rd., Indooroopilly, Queensland, Australia4068
P. Bird
Affiliation:
CSIRO Division of Tropical Animal Production, Meiers Rd., Indooroopilly, Queensland, Australia4068
G. S. Cobon
Affiliation:
Biotech Australia, PO Box 20, Roseville, New South Wales, Australia2069
J. Hungerford
Affiliation:
Biotech Australia, PO Box 20, Roseville, New South Wales, Australia2069
Get access Rights & Permissions [Opens in a new window]

Summary

Increasingly, there is need for methods to control cattle tick (Boophilus microplus) infestations by the use of non-chemical technology. This need is brought about by a mixture of market forces and the failure or inadequacy of existing technology. A recombinant vaccine has now been developed against the tick. This vaccine relies on the uptake with the blood meal of antibody directed against a critical protein in the tick gut. The isolation of the vaccine antigen, Bm86, and its production as a recombinant protein is briefly described. The vaccine has been tested in the field, has been taken through the full registration process and is now in commercial use in Australia. A related development has occurred in Cuba. The potential for improvement of the current vaccine and for the development of similar vaccines against other haematophagous parasites is discussed.

Keywords

Boophilus microplustick vaccinerecombinant vaccinefield trial
Type
Research Article
Information
Parasitology , Volume 110 , Supplement S1: Symposia of the British Society for Parasitology Volume 32:Parasite vaccines , March 1995 , pp. S43 - S50
Copyright
Copyright © Cambridge University Press 1995

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Agbede, R. I. S. & Kemp, D. H. (1986). Immunization of cattle against Boophilus microplus using extracts derived from adult female ticks: histopathology of ticks feeding on vaccinated cattle. International Journal for Parasitology 16, 35–41.CrossRefGoogle ScholarPubMed
Allen, J. R. & Humphreys, S. J. (1979). Immunisation of guinea pigs and cattle against ticks. Nature (London) 280, 491–3.CrossRefGoogle ScholarPubMed
Cobon, G. S. & Willadsen, P. (1990). Vaccines to prevent cattle tick infestations. In New Generation Vaccines (ed. Woodrow, G. C. & Levine, M. M.) pp. 901–917. New York: Marcel Dekker Inc.Google Scholar
de Castro, J. J., Newson, R. M. & Herbert, I. V. (1989). Resistance in cattle against Rhipicephalus appendiculatus with an assessment of cross-resistance to R. pulchellus. (Acari: Ixodidae). Experimental and Applied Acarology 6, 237–4.CrossRefGoogle Scholar
Denhollander, N. & Allen, J. R. (1986). Cross-reactive antigens between a tick, Dermacentor variabilis (Acari: Ixodidae), and a mite, Psoroptes cuniculi (Acari: Psoroptidae). Journal of Medical Entomology 23, 44–50.CrossRefGoogle Scholar
Doolittle, R. F., Feng, D. F. & Johnson, M. S. (1984). Computer-based characterization of epidermal growth factor precursor. Nature (London) 307, 558–60.CrossRefGoogle ScholarPubMed
Gough, J. M. & Kemp, D. H. (1993). Localization of a low abundance membrane protein (Bm86) on the gut cells of the cattle tick Boophilus microplus by immunogold labeling. Journal of Parasitology 79, 900–7.CrossRefGoogle ScholarPubMed
Horn, S. (1987). Ectoparasites of animals and their impact on the economy of South America. In 23rd World Veterinary Congress. Montreal Proceedings.Google Scholar
Jaworski, D. C., Rosell, R., Coons, L. B. & Needham, G. R. (1992). Tick (Acari: Ixodidae) attachment cement and salivary gland cells contain similar immunoreactive polypeptides. Journal of Medical Entomology 29, 305–9.CrossRefGoogle ScholarPubMed
Johnston, L. A. Y., Kemp, D. H. & Pearson, R. D. (1986). Immunization of cattle against Boophilus microplus using extracts derived from adult female ticks: effects of induced immunity on tick populations. International Journal for Parasitology 16, 27–34.CrossRefGoogle ScholarPubMed
Kemp, D. H., Agbede, R. I. S., Johnston, L. A. V. & Gough, J. M. (1986). Immunization of cattle against Boophilus microplus using extracts derived from adult female ticks: feeding and survival of the parasite on vaccinated cattle. International Journal for Parasitology 16, 115–20.CrossRefGoogle ScholarPubMed
Kemp, D. H., Pearson, R. D., Gough, J. M. & Willadsen, P. (1989). Vaccination against Boophilus microplus: localization of antigens on tick gut cells and their interaction with the host immune system. Experimental and Applied Acarology 7, 43–58.CrossRefGoogle ScholarPubMed
Linthicum, K. J., Dickson, D. L. & Logan, T. M. (1992). Feeding efficiency of larval Hyalomma truncatum (Acari: Ixodidae) on hosts previously exposed to ticks. Journal of Medical Entomology 29, 310–13.CrossRefGoogle ScholarPubMed
Nolan, J. & Schnitzerling, H. J. (1986). Drug resistance in arthropod parasites. In Chemotherapy of Parasitic Diseases, (ed. Campbell, W. C. & Rew, R. W.), pp. 603–620. Plenum Pub. Corp.CrossRefGoogle Scholar
Nolan, J., Wilson, J. T., Green, P. E. & Bird, P. E. (1989). Synthetic pyrethroid resistance in field samples of the cattle tick (Boophilus microplus). Australian Veterinary Journal 66, 179–82.CrossRefGoogle ScholarPubMed
Pérez-Sánchez, R., Oleaga-Pérez, A. & Encinas-Grandes, A. (1992). Analysis of the specificity of the salivary antigens of Ornithodoros erraticus for the purpose of serological detection of swine farms harbouring the parasite. Parasite Immunology 14, 201–16.CrossRefGoogle ScholarPubMed
Rand, K. N., Moore, T., Sriskantha, A., Spring, K., Tellam, R., Willadsen, P. & Cobon, G. S. (1989). Cloning and expression of a protective antigen from the cattle tick Boophilus microplus. Proceedings of the National Academy of Sciences USA 86, 9657–61.CrossRefGoogle ScholarPubMed
Riding, G. A., Jarmey, J., McKenna, R. V., Pearson, R., Cobon, G. s. & Willadsen, p.A protective ‘concealed’ antigen from Boophilus microplus: Purification, localization and possible function. Journal of Immunology (In the Press).Google Scholar
Roberts, J. A. (1968). Acquisition by the host of resistance to the cattle tick Boophilus microplus (Canestrini). Journal of Parasitology 54, 657–62.CrossRefGoogle Scholar
Rodriguez, M., Penichet, M. L., Ribiera, R., Mouris, A. E., Cordoves, C., Sanchez, P. A., Labarta, V., Lorenzo-Lucaces, L., Lleonart, R. & De La Fuente, J. (1993). In Manejo y Control de Ecto y Endoparasitos en Grando Bovino Cartagena de Indias, 10 20–22, 1993. Ed. Centre Internacional de Capacitacion en Desarrollo Pecuario (CICADEP) Colombia, 59–63.Google Scholar
Rodriguez, M., Rubiera, R., Penichet, M., Montesinos, R., Cremata, J., Falcon, V., Sanchez, G., Bringas, R., Cordoves, C., Valdes, M., Lleonart, R., Herrera, L. & De La Fuente, J. (1994). High level expression of the B. microplus Bm86 antigen in the yeast Pichia pastoris forming highly immunogenic particles for cattle. Journal of Biotechnology 33, 135–46.CrossRefGoogle Scholar
Schnitzerling, H. J., Nolan, J. & Hughes, S. (1989). Toxicology and metabolism of isomers of flumethrin in larvae of susceptible and resistant strains of the cattle tick Boophilus microplus (Can.) (Acari: Ixodidae), Experimental and Applied Acarology 6, 47–54.CrossRefGoogle Scholar
Sutherst, R. W. & Dallwitz, M. J. (1974). Progress in the development of a population model for the cattle tick Boophilus microplus. Proceedings of the 4th International Congress of Acarology, Akademiai Kiado, Budapest, pp. 557–563.Google Scholar
Tellam, R. L., Smith, D., Kemp, D. H., & Willadsen, P. (1992). Vaccination against ticks. In Animal Parasite Control Utilizing Biotechnology (ed. Yong, W. K.), pp. 303–331. CRC Press, Boca Raton.Google Scholar
Turnbull, I. F., Smith, D. R., Sharp, P. J., Cobon, G. S. & Hynes, M. J. (1990). Expression and secretion in Aspergillus nidulans and Aspergillus niger of a cell surface glycoprotein from the cattle tick, Boophilus microplus, by using the fungal amdS promoter system. Applied and Environmental Microbiology 56, 2847–52.CrossRefGoogle ScholarPubMed
Utech, K. B. W., Wharton, R. H. & Kerr, J. D. (1978). Resistance to Boophilus microplus (Canestrini) in different breeds of cattle. Australian Journal of Agricultural Research 29, 885–95.CrossRefGoogle Scholar
Wheeler, C. M., Coleman, J. L. & Benach, J. L. (1991). Salivary gland antigens of Ixodes dammini are glycoproteins that have interspecies cross-reactivity. Journal of Parasitology 77, 965–73.CrossRefGoogle ScholarPubMed
Wikel, S. K. & Whelen, A. C. (1986). Ixodid-host immune interaction. Identification and characterization of relevant antigens and tick-induced host immunosuppression. Veterinary Parasitology 20, 149–74.CrossRefGoogle ScholarPubMed
Willadsen, P. (1980). Immunity to ticks. Advances in Parasitology 18, 293–313.CrossRefGoogle ScholarPubMed
Willadsen, P., McKenna, R. V. & Riding, G. A. (1988). Isolation from the cattle tick, Boophilus microplus, of antigenic material capable of eliciting a protective immunological response in the bovine host. International Journal for Parasitology 18, 183–9.CrossRefGoogle ScholarPubMed
Willadsen, P., Riding, G. A., McKenna, R. V., Kemp, D. H., Tellam, R. L., Nielsen, J. N., Lahnstein, J., Cobon, G. s. & Gough, J. M. (1989). Immunologic control of a parasitic arthropod: Identification of a protective antigen from Boophilus microplus. Journal of Immunology 143, 1346–51.CrossRefGoogle ScholarPubMed
Willadsen, P. & McKenna, R. V. (1991). Vaccination with ‘concealed’ antigens: myths or reality? Parasite Immunology 13, 605–16.CrossRefGoogle ScholarPubMed
Xu, Bixiong & Powell, M. R. (1991). Carbohydrate epitopes are responsible for antibody cross-reactivity in Trypanosoma cruzi-ifected mice. Journal of Parasitology 77, 808–10.CrossRefGoogle ScholarPubMed