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Clinical features and management of Plasmodium knowlesi infections in humans

Published online by Cambridge University Press:  26 January 2017

CYRUS DANESHVAR ,
TIMOTHY WILLIAM  and
TIMOTHY M. E. DAVIS
CYRUS DANESHVAR*
Affiliation:
Department of Respiratory Medicine, Plymouth Hospitals NHS Trust, Plymouth, UK
TIMOTHY WILLIAM
Affiliation:
Queen Elizabeth Hospital, Kota Kinabalu, Malaysia Infectious Diseases Society Sabah-Menzies School of Health Research Clinical Research Unit, Kota Kinabalu, Malaysia Jesselton Medical Centre, Kota Kinabalu, Malaysia
TIMOTHY M. E. DAVIS
Affiliation:
School of Medicine and Pharmacology, University of Western Australia, Fremantle Hospital, Western Australia, Australia
*
*Corresponding author. Department of Respiratory Medicine, Plymouth Hospitals NHS Trust, Derriford, Plymouth PL6 8DH, UK. E-mail: [email protected]
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Summary

Plasmodium knowlesi is a simian malaria of primarily the macaque species of South East Asia. While it was known that human infections could be induced during the years of malariotherapy, naturally occurring P. knowlesi human infections were thought to be rare. However, in 2004, knowlesi infections became recognized as an important infection amongst human populations in Sarawak, Malaysian Borneo. Since then, it has become recognized as a disease affecting people living and visiting endemic areas across South East Asia. Over the last 12 years, clinical studies have improved our understanding of this potentially fatal disease. In this review article the current literature is reviewed to give a comprehensive description of the disease and treatment.

Keywords

Plasmodium knowlesimalariaclinicalcomplicatedseveretreatmentantimalarialsimian
Type
Special Issue Review
Information
Parasitology , Volume 145 , Special Issue 1: Plasmodium knowlesi , January 2018 , pp. 18 - 31
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Copyright
Copyright © Cambridge University Press 2017 

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