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Changes in the adenylate energy charge of Nippostrorigylus brasiliensis and Nematodirus battus during the development of immunity to these nematodes in their hosts

Published online by Cambridge University Press:  06 April 2009

A. J. Ballantyne
Affiliation:
Department of Pure and Applied Zoology, University of Leeds, Leeds LS2 9JT
M. J. Sharpe
Affiliation:
Department of Pure and Applied Zoology, University of Leeds, Leeds LS2 9JT
D. L. Lee
Affiliation:
Department of Pure and Applied Zoology, University of Leeds, Leeds LS2 9JT

Summary

Infection of rats with 2000 infective juveniles of Nippostrongylus brasiliensis and of lambs with 60000 infective juveniles of Nematodirus battus results in a well-marked immunity to these nematodes in their respective hosts. There is a fall in the adenylate energy charge value of these nematodes during the course of these infections, reaching values of 0·37 in males and 0·27 in females of N. brasiliensis, and 0·31 in males and 0·23 in females of N. battus towards the end of the infections. In hosts given relatively small numbers of infective juveniles, the values for the nematodes removed from the hosts late in the infection remain at a relatively high level. These results indicate that the immune response of the host may affect the energy status of these nematodes, and this could help to explain their subsequent expulsion from the immune host.

Type
Research Article
Copyright
Copyright © Cambridge University Press 1978

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References

REFERENCES

Atkinson, D. E. & Walton, G. M. (1967). Adenosine triphosphate conservation in metabolic regulation: rat liver citrate cleavage enzyme. Journal of Biological Chemistry 242, 3239–41.CrossRefGoogle ScholarPubMed
Atkinson, H. J. & Ballantyne, A. J. (1977). Changes in the adenine nucleotide content of cysts of Globodera rostochiensis associated with the hatching of juveniles. Annals of Applied Biology 87, 167–74.CrossRefGoogle Scholar
Ball, W. J. & Atkinson, D. E. (1975). Adenylate energy charge in Saccharomyces cerevisiae during starvation. Journal of Bacteriology 121, 975–82.Google Scholar
Beis, I. & Barrett, J. (1975). Energy metabolism in developing Ascaris lumbricoides eggs. II. The steady state content of intermediary metabolites. Developmental Biology 42, 188–95.CrossRefGoogle ScholarPubMed
Chapman, A. G., Fall, L. & Atkinson, D. E. (1971). Adenylate energy charge in Escherichia coli during growth and starvation. Journal of Bacteriology 108, 1072–86.CrossRefGoogle ScholarPubMed
Ching, T. H. & Ching, K. K. (1972). Content of adenosine phosphates and adenylate energy charge in germinating Ponderosa pine seeds. Plant Physiology 50, 536–40.Google Scholar
Crofton, H. D. & Thomas, R. J. (1954). A further description of Nematodirus battus Crofton & Thomas, 1951. Journal of Helminthology 28, 119–22.Google Scholar
Dean, R. B. & Dixon, W. J. (1951). Simplified statistics for small numbers of observations. Analytical Chemistry 23, 636–8.Google Scholar
Drewes, L. R. & Gilboe, D. D. (1973). Cerebral metabolite and adenylate energy charge recovery following 10 mm of anoxia. Biochimica et Biophysica Acta 320, 701–6.Google Scholar
Edwards, A. J., Burt, J. S. & Ogilvie, B. M. (1971). The effect of immunity upon some enzymes of the parasitic nematode Nippostrongylus brasiliensis. Parasitology 62, 339–47.Google Scholar
Gibson, T. E. & Everett, G. (1963). The development of resistance by sheep to infection with the nematode Nematodirus battus. British Veterinary Journal 119, 214–18.Google Scholar
Jarowek, D., Gruber, W. & Bergmeyer, H. U. (1974). Adenosine-5'-diphosphate and adenosine-5'-monophosphate. In Methods of Enzymatic Analysis, vol. 4, 2nd edition (ed. Bergmeyer, H. U.). New York: Academic Press.Google Scholar
Lee, D. L. (1969). Changes in adult Nippostrongylus brasiliensis during development of immunity to this nematode in rats. 1. Changes in ultrastructure. Parasitology 59, 2938.Google Scholar
Lee, D. L. (1972). Structural and biochemical changes in Nippostrongylus brasiliensis during development of immunity to this nematode in rats. In Comparative Biochemistry of Parasites (ed. Van den Bossche, H.). New York: Academic Press.Google Scholar
Lee, D. L. & Martin, J. (1976). Changes in Nematodirus battus associated with the development of immunity to this nematode in lambs. In Biochemistry of Parasites and Host– Parasite Relationships (ed. Van den Bossche, H.), pp. 311–18. Amsterdam: North-Holland Publishing Company.Google Scholar
Martin, J. & Lee, D. L. (1976). Observations on crystals found in the intestine of Nematodirus battus during the development of immunity to this nematode in lambs. Parasitology 72, 7580.CrossRefGoogle ScholarPubMed
Montague, M. D. & Dawes, E. A. (1974). The survival of Peptococcus prevotii in relation to the adenylate energy charge. Journal of General Microbiology 80, 291–9.CrossRefGoogle Scholar
Ogilvie, B. M. & Hockley, D. J. (1968). Effect of immunity on Nippostrongylus brasiliensis adult worms: reversible and irreversible changes in infectivity, reproduction and morphology. Journal of Parasitology 54, 1073–84.CrossRefGoogle ScholarPubMed
Ogilvie, B. M. & Jones, V. E. (1971). Nippostrorigylus brasiliensis: a review of immunity and the host/parasite relationship in the rat. Experimental Parasitology 29, 138–77.Google Scholar
Snedecor, G. W. & Cochran, W. G. (1967). Statistical Methods. Iowa: Iowa State University Press.Google Scholar
Strehler, B. L. (1974). Adenosine-5'-triphosphate and creatine phosphate. In Methods of Enzymatic Analysis, vol. 4, 2nd edition (ed. Bergmeyer, H. U.). New York: Academic Press.Google Scholar
Yokogawa, S. (1920). A new nematode from the rat. Journal of Parasitology 7, 2933.Google Scholar