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Can Wolbachia modulate the fecundity costs of Plasmodium in mosquitoes?

Published online by Cambridge University Press:  08 August 2017

F Zélé Open the ORCID record for F Zélé [Opens in a new window] ,
J Denoyelle ,
O Duron  and
A Rivero
F Zélé*
Affiliation:
cE3c: centre for Ecology, Evolution and Environmental changes, Faculdade de Ciencias, Universidade de Lisboa, Edificio C2, 3° Piso Campo Grande, 1749016 Lisbon, Portugal
O Duron
Affiliation:
Maladies Infectieuses et Vecteurs: Ecologie, Génétique, Evolution et Contrôle, CNRS (UMR 5290), Centre de Recherche IRD, 911 Avenue Agropolis, 34394 Montpellier, France Institut des Sciences de l'Evolution, CNRS (UMR 5554), University of Montpellier, 34090 Montpellier, France
A Rivero
Affiliation:
Maladies Infectieuses et Vecteurs: Ecologie, Génétique, Evolution et Contrôle, CNRS (UMR 5290), Centre de Recherche IRD, 911 Avenue Agropolis, 34394 Montpellier, France
*
Author for correspondence: F. Zélé, E-mail: [email protected]
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Abstract

Vertically transmitted parasites (VTPs) such as Wolbachia are expected not only to minimize the damage they inflict on their hosts, but also to protect their hosts against the damaging effects of coinfecting parasites. By modifying the fitness costs of the infection, VTPs can therefore play an important role in the evolution and epidemiology of infectious diseases.

Using a natural system, we explore the effects of a Wolbachia–Plasmodium co-infection on mosquito fecundity. While Plasmodium is known to frequently express its virulence by partially castrating its mosquito vectors, the effects of Wolbachia infections on mosquito fecundity are, in contrast, highly variable. Here, we show that Plasmodium drastically decreases the fecundity of mosquitoes by ca. 20%, and we provide the first evidence that this decrease is independent of the parasite's burden. Wolbachia, on the other hand, increases fecundity by roughly 10%, but does not alter the tolerance (fecundity–burden relationship) of mosquitoes to Plasmodium infection.

Although Wolbachia-infected mosquitoes fare overall better than uninfected ones, Wolbachia does not confer a sufficiently high reproductive boost to mosquitoes to compensate for the reproductive losses inflicted by Plasmodium. We discuss the potential mechanisms and implications underlying the conflicting effects of these two parasites on mosquito reproduction.

Keywords

P. relictumCulex pipiensavian malariablood feedingresource allocationmutualism
Type
Research Article
Information
Parasitology , Volume 145 , Issue 6 , May 2018 , pp. 775 - 782
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Copyright
Copyright © Cambridge University Press 2017 

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Footnotes

†

Co-last authors.

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