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Anthelmintic efficacy of cinnamaldehyde and cinnamic acid from cortex cinnamon essential oil against Dactylogyrus intermedius

Published online by Cambridge University Press:  07 October 2015

FEI LING ,
CHAO JIANG ,
GUANGLU LIU ,
MINGSHUANG LI  and
GAOXUE WANG
FEI LING
Affiliation:
College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi 712100, China
CHAO JIANG
Affiliation:
College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi 712100, China
GUANGLU LIU
Affiliation:
College of Science, Northwest A&F University, Yangling, Shaanxi 712100, China
MINGSHUANG LI
Affiliation:
National Fisheries Technical Extension Center, 100125, China
GAOXUE WANG*
Affiliation:
College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi 712100, China
*
* Corresponding author. College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi 712100, China. E-mail: [email protected]
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Summary

Utilization of chemical pesticide to control monogenean diseases is often restricted in many countries due to the development of pesticide resistance and concerns of chemical residues and environmental contamination. Thus, the use of antiparasitic agents from plants has been explored as a possible way for controlling monogenean infections. Extracts from Cinnamomum cassia were investigated under in vivo conditions against Dactylogyrus intermedius in goldfish. The two bioactive compounds, cinnamaldehyde and cinnamic acid, were identified using nuclear magnetic resonance and electrospray ionization mass spectrometry. The 48 h median effective concentrations (EC50) for these compounds against D. intermedius were 0·57 and 6·32 mg L−1, respectively. The LD50 of cinnamaldehyde and cinnamic acid were 13·34 and 59·66 mg L−1 to goldfish in 48 h acute toxicity tests, respectively. These data confirm that cinnamaldehyde is effective against D. intermedius, and the cinnamaldehyde exhibits potential for the development of a candidate antiparasitic agent.

Keywords

Cinnamonanthelmintic efficacymonogeneancinnamaldehydecinnamic acid
Type
Research Article
Information
Parasitology , Volume 142 , Issue 14 , December 2015 , pp. 1744 - 1750
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Copyright
Copyright © Cambridge University Press 2015 

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