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Ancylostoma ceylanicum in the hamster: observations on the host—parasite relationship during primary infection

Published online by Cambridge University Press:  06 April 2009

P. Garside  and
J. M. Behnke
P. Garside
Affiliation:
MRC Experimental Parasitology Research Group, Department of Zoology, University of Nottingham, University Park, Nottingham NG7 2RD
J. M. Behnke
Affiliation:
MRC Experimental Parasitology Research Group, Department of Zoology, University of Nottingham, University Park, Nottingham NG7 2RD
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Summary

The course of primary infection with a hamster-adapted strain of Ancylostoma ceylanicum was studied in inbred DSN and randomly bred WO/GD and WO/CR hamsters. Infective larvae were administered orally and began to develop in the small intestine without embarking on a tissue migration. Only the occasional larva was detected in other organ sites. It was concluded that the developing larvae moulted on days 3–4 and again to the pre-adult stage about 9–11 days post-infection. Worm burdens in infected hamsters were stable for at least 11 weeks after infection. There was no sudden expulsive phase and some adult worms survived for over 200 days. Overall the sex ratio of worms in groups of hamsters killed concurrently was about 50% although occasionally the ratio was biased in favour of one sex in individual animals. The blood packed cell volume (PCV) was significantly depressed 2 weeks following infection and continued to decline until a point of stability was achieved 4–5 weeks post-infection. The PCV subsequently remained depressed throughout the period of observation. Infected hamsters lost weight if kept in groups, but not when housed in separate cages. Groups of animals which lost weight did not recover to normal values within 11 weeks of infection. It is suggested that this model of hookworm infection has scope for exploring aspects of the host-parasite relationship which the canine models cannot fulfill adequately.

Keywords

Ancylostoma ceylanicuminfection modelhost-parasite relationship
Type
Research Article
Information
Parasitology , Volume 98 , Issue 2 , April 1989 , pp. 283 - 289
Copyright
Copyright © Cambridge University Press 1989

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References

REFERENCES

Anten, J. F. G. & Zuidema, P. J. (1964). Ankylostomiasis biji uit West Nieuw-Guinea teruggekeerde dienstplichtigen. Nederlands Tijidschrift voor Geneeskunde 108, 1664–9.Google Scholar
Areekul, S., Saenghirun, C. & Ukoskit, K. (1975). Studies on the pathogenicity of Ancylostoma ceylanicum. 1. Blood loss in experimental dogs. Southeast Asian Journal of Tropical Medicine and Public Health 6, 235–40.Google Scholar
Banerjee, D., Prakash, O. & Deo, M. G. (1970). Studies on the early stage infection of Ancylostoma caninum in mice. Indian Journal of Medical Research 58, 1321.Google ScholarPubMed
Behnke, J. M. 1987). Do hookworms elicit protective immunity in man ? Parasitology Today 3, 200–6.CrossRefGoogle ScholarPubMed
Behnke, J. M. & Parish, H. A. (1979). Nematospiroides dubius: arrested development of larvae in immune mice. Experimental Parasitology 47, 116–27.CrossRefGoogle ScholarPubMed
Behnke, J. M. & Pritchard, D. I. P. (1987). Necator americanus in neonatally infected hamsters. The time-course of infection and antibody response to the surface antigens of L4 and adult worms. Transactions of the Royal Society of Tropical Medicine and Hygiene 81, 967–72.CrossRefGoogle Scholar
Behnke, J. M., Wells, C. & Brown, J. (1986). An improved technique for experimental infections with skin penetrating nematode larvae. International Journal for Parasitology 16, 461–4.CrossRefGoogle ScholarPubMed
Caradoc-davies, T. H. (1985). Tadpole. Netherlands: Elsevier Science Publishers BV.Google Scholar
Carroll, S. M. & Grove, D. I. (1984). Parasitological, hematologic and immunologic responses in acute and chronic infections of dogs with Ancylostoma ceylanicum: a model of human hookworm infection. Journal of Infectious Diseases 150, 284–94.CrossRefGoogle Scholar
Carroll, S. M. & Grove, D. I. (1986). Experimental infections of humans with Ancylostoma ceylanicum: clinical, parasitological, haematological and immunological findings. Tropical and Geographical Medicine 38, 38–45.Google ScholarPubMed
Carroll, S. M., Grove, D. I., Dawkins, H. J. S., Mitchell, G. F. & Whitten, L. K. (1983). Infections with a Malaysian dog strain of Ancylostoma ceylanicum in outbred, inbred and immunocompromised mice. Parasitology 87, 229–38.CrossRefGoogle ScholarPubMed
Chowdurry, A. B. & Schad, G. A. (1972). Ancylostoma ceylanicum: a parasite of man in Calcutta and environs. American Journal of Tropical Medicine and Hygiene 21, 300–1.CrossRefGoogle Scholar
Gilles, H. M. (1985). Selective primary health care: strategies for control of disease in the developing world. XVII Hookworm infection and anaemia. Reviews in Infectious Diseases 7, 111–18.CrossRefGoogle Scholar
Menon, S. & Bhopale, M. K. (1985). Ancylostoma ceylanicum (Looss, 1911) in golden hamsters (Mesocricetus auratus): pathogenicity and humoral immune response to a primary infection. Journal of Helminthology 59, 143–6.CrossRefGoogle ScholarPubMed
Ray, D. K., Bhopale, K. K. & Shrivastava, V. B. (1972). Migration and growth of Ancylostoma ceylanicum in golden hamsters Mesocricetus auratus. Journal of Helminthology 46, 357–62.CrossRefGoogle ScholarPubMed
Soh, C. T. (1958). The distribution and persistence of hookworm larvae in the tissues of mice in relation to species and to routes of innoculation. Journal of Parasitology 44, 515–19.CrossRefGoogle Scholar
Sokal, R. R. & Rohlf, F. J. (1969). Biometry. San Francisco: Freeman.Google Scholar
Visen, P. K. S., Katiyar, J. C. & Sen, A. B. (1984). Studies on infectivity, longevity and fecundity of Ancylostoma ceylanicum in golden hamsters. Journal of Helminthology 58, 159–63.CrossRefGoogle ScholarPubMed
Wells, C. & Behnke, J. M. (1988). Acquired immunity to the human hookworm Necator americanus in mice. Parasite Immunology 10, 493–505.CrossRefGoogle Scholar
Yoshida, Y., Okamoto, K. & Chui, J. K. (1971). Experimental infection of man with Ancylostoma ceylanicum Looss, 1911. Chinese Journal of Microbiology 4, 157–67.Google Scholar