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Anamnestic responses in pigs to the Taenia solium TSOL18 vaccine and implications for control strategies

Published online by Cambridge University Press:  19 February 2016

MARSHALL W. LIGHTOWLERS ,
MERITXELL DONADEU ,
M. ELAIYARAJA ,
KAPIL MAITHAL ,
K. ANAND KUMAR ,
CHARLES G. GAUCI ,
SIMON M. FIRESTONE ,
PATXI SARASOLA  and
TIM G. ROWAN
MARSHALL W. LIGHTOWLERS*
Affiliation:
Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Veterinary Clinical Centre, 250 Princes Highway, Werribee, Victoria 3030, Australia
MERITXELL DONADEU
Affiliation:
Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Veterinary Clinical Centre, 250 Princes Highway, Werribee, Victoria 3030, Australia
M. ELAIYARAJA
Affiliation:
Indian Immunologicals Limited, ‘Rakshapuram’, Gachibowli Post, Hyderabad - 500 032, Telangana, India
KAPIL MAITHAL
Affiliation:
Indian Immunologicals Limited, ‘Rakshapuram’, Gachibowli Post, Hyderabad - 500 032, Telangana, India
K. ANAND KUMAR
Affiliation:
Indian Immunologicals Limited, ‘Rakshapuram’, Gachibowli Post, Hyderabad - 500 032, Telangana, India
CHARLES G. GAUCI
Affiliation:
Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Veterinary Clinical Centre, 250 Princes Highway, Werribee, Victoria 3030, Australia
SIMON M. FIRESTONE
Affiliation:
Faculty of Veterinary and Agricultural Sciences, Asia-Pacific Centre for Animal Health, The University of Melbourne, Parkville, Victoria 3010, Australia
PATXI SARASOLA
Affiliation:
Ondax Scientific SL, Aptdo. 336, 20280 Hondarribia, Spain
TIM G. ROWAN
Affiliation:
GALVmed, Doherty Building, Pentlands Science Park, Bush Loan, Edinburgh EH26 0PZ, Scotland, UK
*
* Corresponding author. Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Veterinary Clinical Centre, 250 Princes Highway, Werribee, Victoria 3030, Australia. E-mail: [email protected]
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Summary

Specific antibody responses were assessed in pigs immunized with the Taenia solium vaccine TSOL18. Anti-TSOL18 responses were compared 2 weeks after secondary immunization, where the interval between primary and secondary immunization was 4, 8, 12, 16 or 20 weeks. All animals responded to the vaccine and there was no diminution in antibody responses in animals receiving their second injection after an interval up to 20 weeks. Pigs receiving vaccinations at an interval of 12 weeks developed significantly increased antibody responses compared with animals receiving immunizations 4 weeks apart (P = 0·046). The ability to deliver TSOL18 vaccination effectively where the revaccination schedule can be delayed for up to 12–16 weeks in pigs increases the options available for designing T. solium control interventions that incorporate TSOL18 vaccination.

Keywords

Taenia soliumpigvaccineTSOL18anamnestic response
Type
Research Article
Information
Parasitology , Volume 143 , Issue 4 , April 2016 , pp. 416 - 420
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Copyright
Copyright © Cambridge University Press 2016 

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