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An experimental model for fatal malaria due to TNF-α-dependent hepatic damage

Published online by Cambridge University Press:  01 April 2008

E. SEIXAS ,
P. OLIVEIRA ,
J. F. MOURA NUNES  and
A. COUTINHO
E. SEIXAS*
Affiliation:
Instituto Gulbenkian de Ciência, Oeiras, Portugal
P. OLIVEIRA
Affiliation:
Instituto Português de Oncologia, Lisboa, Portugal
J. F. MOURA NUNES
Affiliation:
Instituto Português de Oncologia, Lisboa, Portugal
A. COUTINHO
Affiliation:
Instituto Gulbenkian de Ciência, Oeiras, Portugal
*
*Corresponding author: Instituto Gulbenkian de Ciência, Oeiras, Portugal. Tel: +351 21 446 45 17. Fax: +351 21 440 79 70. E-mail: [email protected]
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Summary

While BALB/c mice survive infection with blood stages of Plasmodium chabaudi chabaudi (AS), 70% of DBA/2 mice die by day 9–11 of infection, both strains controlling parasitaemia. We describe here that infection of DBA/2 mice results in extensive, multifocal hepatocyte death. Antibody neutralization of TNF-α prevents both liver damage and death.

Keywords

Plasmodium chabaudi chabaudiTNF-αliverblood-stage infection
Type
Original Articles
Information
Parasitology , Volume 135 , Issue 6 , May 2008 , pp. 683 - 690
Copyright
Copyright © 2008 Cambridge University Press

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