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Alternative pathways in Angiostrongylus cantonensis (Metastrongyloidea: Angiostrongylidae) transmission

Published online by Cambridge University Press:  28 September 2020

David Modrý Open the ORCID record for David Modrý [Opens in a new window] ,
Barbora Fecková Open the ORCID record for Barbora Fecková [Opens in a new window] ,
Barbora Putnová ,
Sheina Macy Manalo  and
Domenico Otranto Open the ORCID record for Domenico Otranto [Opens in a new window]
David Modrý*
Affiliation:
University of Veterinary and Pharmaceutical Sciences, Palackého tř. 1946/1, Brno, Czech Republic Biology Centre, Czech Academy of Sciences, 370 05, České Budějovice, Czech Republic Department of Botany and Zoology, Faculty of Science, Masaryk University, Kotlářská 6, 611 37, Brno, Czech Republic
Barbora Fecková
Affiliation:
University of Veterinary and Pharmaceutical Sciences, Palackého tř. 1946/1, Brno, Czech Republic
Barbora Putnová
Affiliation:
University of Veterinary and Pharmaceutical Sciences, Palackého tř. 1946/1, Brno, Czech Republic
Sheina Macy Manalo
Affiliation:
University of Veterinary and Pharmaceutical Sciences, Palackého tř. 1946/1, Brno, Czech Republic Department of Veterinary Paraclinical Sciences, University of the Philippines Los Baňos, Philippines
Domenico Otranto
Affiliation:
Dipartimento di Medicina Veterinaria, Università degli Studi di Bari, Bari, Italy Faculty of Veterinary Sciences, Bu-Ali Sina University, Hamedan, Iran
*
Author for correspondence: David Modrý, E-mail: [email protected]
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Abstract

In order to elucidate the infection pathways of third stage larvae (L3) of Angiostrongylus cantonensis, we performed experiments to assess: (i) the shedding of L3 from two species of experimental veronicellid slugs drowned in water and the ratio of emerged larvae, (ii) the transmission of viable L3 from drowned terrestrial gastropods to aquatic snails, and (iii) the transmission of viable L3 between terrestrial snails. Molluscs were experimentally infected by first stage larvae (L1) of A. cantonensis. Significantly more L3 larvae were released from Veronicella cubensis than from Veronicella sloanei. Numerous L3 were observed in the muscular foot, and also in the connective tissue between internal organs. Experimental exposure of P. maculata to L3 of A. cantonensis liberated from other gastropod species led to their infection and the infectivity of larvae after intermediesis was demonstrated by infection of laboratory rats (Rattus norvegicus). The transmission of L3 was observed in three out of four experiment replications and L3 were retrieved from 6 out of 24 Subulina octona snails. The infected synanthropic molluscs represent a key component in the epidemiology of human infections by A. cantonensis. Escape of L3 larvae from bodies of dead snails or slugs and their ability to infect further gastropod hosts (intermediesis) represents a public health risk. Thus, control of molluscs living in peri-domestic environment is an essential part of prevention of human infections.

Keywords

Angiostrongylus cantonensisdiseaseemergingexperimental infectionintermediesiszoonosis
Type
Research Article
Information
Parasitology , Volume 148 , Special Issue 2: 6th International Workshop on Angiostrongylus and Angiostrongyliasis, Hilo, Hawai'i, USA, January, 2020 , February 2021 , pp. 167 - 173
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Copyright
Copyright © The Author(s) 2020. Published by Cambridge University Press

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Footnotes

*

Authors contributed equally

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