Hostname: page-component-586b7cd67f-dlnhk Total loading time: 0 Render date: 2024-11-29T01:55:37.238Z Has data issue: false hasContentIssue false
  • English
  • Français

Acquired immunity to Trichuris muris in the albino laboratory mouse

Published online by Cambridge University Press:  06 April 2009

D. Wakelin
D. Wakelin
Affiliation:
Department of Zoology, Bedford College, London, N. W. 1
Get access Rights & Permissions [Opens in a new window]

Extract

After infection with the nematode Trichuris muris 70–75% of mice of the Schofield strain developed an immunity to the parasite and eliminated the worms between the 16th and 19th days after infection. In these mice the acquired immunity persisted for at least 3 months and prevented the establishment of subsequent infections.

In 25–30% of the mice immunity was not produced and infections developed into mature worms. These non-resistant mice remained susceptible to further infection.

The development and action of the immune response were suppressed completely by the administration of cortisone acetate.

Type
Research Article
Information
Parasitology , Volume 57 , Issue 3 , August 1967 , pp. 515 - 524
Copyright
Copyright © Cambridge University Press 1967

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Campbell, W. C. (1963). Spontaneous cure in Trichuris muris infections in albino mice and its suppression by cortisone. J. Parasit. 49, 628–32.CrossRefGoogle ScholarPubMed
Campbell, W. C. & Collette, J. V. (1962). Effect of cortisone upon infection with Trichuris muris in albino mice. J. Parasit. 48, 933–4.CrossRefGoogle Scholar
Fahmy, M. A. M. (1954). An investigation on the life cycle of Trichuris muris. Parasitology 44, 50–7.CrossRefGoogle ScholarPubMed
Keeling, J. E. D. (1961). Experimental trichuriasis. I. Antagonism between Trichuris muris and Aspiculuris tetraptera in the albino mouse. J. Parasit. 47, 641–6.CrossRefGoogle ScholarPubMed
Larsh, J. E. (1963). Experimental trichiniasis. Adv. Parasit. 1, 213–86.CrossRefGoogle ScholarPubMed
Ogilvie, B. M. (1965). Use of cortisone derivatives to inhibit resistance to Nippostrongylus brasiliensis and to study the fate of parasites in resistant hosts. Parasitology 55, 723–30.CrossRefGoogle Scholar
Pike, E. H. (1965). Bionomic, blood, and chromium51 investigations of Trichuris muris and studies with two related species. Diss. Abstr. 25, 7430–1.Google Scholar
Powers, K. G. (1962). Bionomics of the genus Trichuris Roederer, 1761, in sheep. Diss. Abstr. 22, 2116–17.Google Scholar
Shikhobalova, N. P. (1937). Experimental study of the chemotherapy of trichocephalosis. I. Trichocephalosis of white mice. Medskya Parazit. 6, 389–400.Google Scholar
Shikhobalova, N. P. (1940). Immunity in helminthoses. I. Immunity of white mice to superinvasion of Trichocephalus muris. Medskaya Parazit. 9, 245–53.Google Scholar
Shikhobalova, N. P. (1941 a). Immunity in helminthoses. II. Effect of the intensity of infection on the development of Trichocephalus in white mice. Medskaya Parazit. 10, 340–9. (Cited by Skrjabin, Shikhobalova & Orlov, 1957).Google Scholar
Shikhobalova, N. P. (1941 b). Immunity in helminthoses. III. Effect of the intensity of primary infection on the degree of resistance of white mice to Trichocephalus. Medskaya Parazit. 10, 349–52. (Cited by Skrjabin et al. 1957.)Google Scholar
Skrjabin, K. I., Shikhobalova, N. P. & Orlov, I. V. (1957). Trichocephalidae and Capillariidae of Animals and Man and the Diseases caused by them. Vol. 4. Principles of Nematology, 587 pp. Akad. Nauk U.S.S.R.Google Scholar
Soulsby, E. J. L. (1961). Immune mechanisms in helminth infections. Vet. Rec. 73, 1053–8.Google Scholar
Worley, D. E., Meisenhelder, J. E., Sheffield, H. G. & Thompson, P. E. (1962). Experimental studies on Trichuris muris in mice with an appraisal of its use for evaluating anthelmintics. J. Parasit. 48, 433–7.CrossRefGoogle ScholarPubMed
Whur, P. (1966). Relationship of globule leucocytes to gastrointestinal nematodes in the sheep, and Nippostrongylus brasiliensis and Hymenolepis nana infections in rats. J. comp. Path. Ther. 76, 57–65.CrossRefGoogle ScholarPubMed