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Taenia ovis recombinant vaccine – ‘quo vadit’

Published online by Cambridge University Press:  06 April 2009

M. D. Rickard ,
G. B. L. Harrison ,
D. D. Heath  and
M. W. Lightowlers
M. D. Rickard
Affiliation:
CSIRO Division of Animal Health, Private Bag No 1, Parkville, Victoria 3032, Australia
G. B. L. Harrison
Affiliation:
Agresearch, Wallaceville Animal Research Centre, PO Box 40063, Upper Hutt, New Zealand
D. D. Heath
Affiliation:
Agresearch, Wallaceville Animal Research Centre, PO Box 40063, Upper Hutt, New Zealand
M. W. Lightowlers
Affiliation:
Veterinary Clinical Centre, Melbourne University, Princes Highway, Werribee, Victoria 3030, Australia
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Summary

Several years have elapsed since the publication by Johnson et al. (1989) of the cloning of a recombinant antigen from the cestode parasite Taenia ovis which stimulated high levels of protective immunity in sheep. A great deal of subsequent research and development was necessary to bring the fledgling vaccine to the point of being a registered commercial product. The results of these subsequent studies are dealt with briefly in this paper, including the results of field trials. The T. ovis vaccine was registered by the New Zealand Animal Remedies Board in February 1994. Where then is the commercial product ? This paper gives a background to market problems which have emerged through the politics (and realities) of the NZ T. ovis control campaign. It serves as notice that the best science dedicated to producing vaccines or products for parasitic, or other, diseases often faces significant hurdles in the real world of commerce and politics.

Keywords

Taenia ovisrecombinant antigenscestode vaccinesmaternal antibodymarket problems
Type
Research Article
Information
Parasitology , Volume 110 , Supplement S1: Symposia of the British Society for Parasitology Volume 32:Parasite vaccines , March 1995 , pp. S5 - S10
Copyright
Copyright © Cambridge University Press 1995

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References

Harrison, G. B. L., Heath, D. D., Dempster, R. P., Lawrence, S. B., Lightowlers, M. W. & Rickard, M. D. (1993 a). Identification of host-protective antigens of Taenia ovis oncospheres. International Journal for Parasitology, 23, 41–50.CrossRefGoogle ScholarPubMed
Harrison, G. B. L., Dempster, R. P., Robinson, C. M., Heath, D. D., Lightowlers, M. W. & Rickard, M. D. (1993 b). Pilot scale field trial to test efficacy of Taenia ovis recombinant vaccine. Proceedings of Vaccines, Lorne, Australia, 1993.Google Scholar
Harrison, G., Robinson, C., Wakelin, R., Lawrence, S. & Heath, D. (1993 c). Field trials with recombinant Taenia ovis vaccine. Proceedings of the Australian Society for Parasitology,September 1993.Google Scholar
Heath, D. D., Lawrence, S. B., Ralston, M. J., Harrison, G. B. L., Dempster, R. P., Robinson, C., Lightowlers, M. W., Gaucci, C. & Newton, S. (1993). New protective cloned antigens of Taenia ovis. Proceedings of the New Zealand Society for Parasitology,August, 1993.Google Scholar
Johnson, K. S., Harrison, G. B. L., Lightowlers, M. W., O'Hoy, K. L., Cougle, W. G., Dempster, R. B., Lawrence, S. B., Vinton, J. G., Heath, D. D. & Rickard, M. D. (1989). Vaccination against ovine cysticercosis using a defined recombinant antigen. Nature 338, 585–87.CrossRefGoogle ScholarPubMed
Lawrence, S. B., Harrison, G. B. L., Robinson, C. M. & Heath, D. D. (1993). Vaccination of lambs against Taenia ovis in the presence of maternal antibody. Proceedings of the New Zealand Society for Parasitology,August, 1993.Google Scholar
Lawson, J. R. (1994). Hydatid disease and sheep measles: the history of their control and the economics of a recent change of control policy. New Zealand Journal of Zoology 21, 83–9.CrossRefGoogle Scholar
Lawson, J. R., Roberts, M. G., Gemmell, M. A. & Best, S. J. (1988). Population dynamics in echinococcosis and cysticercosis: economic assessment of control strategies for Echinococcus granulosus, Taenia ovis and Taenia hydatigena. Parasitology 97, 177–91.CrossRefGoogle Scholar
Lightowlers, M. W., Gemmell, M. A., Harrison, G. B. L., Heath, D. D., Rickard, M. D. & Roberts, M. G. (1992). Control of tissue parasites. In Animal Parasite Control Utilising Biotechnology (ed. Young, W. K.), pp. 171–98. United States: CRC Press.Google Scholar
Lightowlers, M. W. & Rickard, M. D. (1993). Vaccination against cestode parasites. Immunology and Cell Biology 71, 443–51.CrossRefGoogle ScholarPubMed
Rickard, M. D. (1989). A success in veterinary parasitology: cestode vaccines. In New Strategies in Parasitology (ed. McAdam, P. P. W. J.), pp. 3–14. Edinburgh, London, Melbourne & New York: Churchill Livingstone.Google Scholar
Rickard, M. D. & Williams, J. F. (1982). Hydatidosis/Cysticercosis: Immune mechanisms and immunisation against infection. Advances in Parasitology 21, 229–96.CrossRefGoogle ScholarPubMed