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Schistosoma mansoni: structural damage and tegumental repair after in vivo treatment with praziquantel

Published online by Cambridge University Press:  06 April 2009

M. K. Shaw  and
D. A. Erasmus
M. K. Shaw
Affiliation:
Department of Zoology, University College, P.O. Box 78, CardiffCF1 1XL
D. A. Erasmus
Affiliation:
Department of Zoology, University College, P.O. Box 78, CardiffCF1 1XL
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Summary

The long-term, in vivo effects of a single, subcurative dose (200 mg/kg body weight of mouse) of praziquantel on the structure of adult Schistosoma mansoni and on the process and speed of tegumental repair are described. In both male and female worms praziquantel caused often extensive damage to the tegument, in the form of surface blebbings, swellings and lesions, and vacuolization and disruption of the subtegumental tissues. Repair of the drug-induced tegumental damage occurred slowly with partial and, more rarely, complete repair only being seen after 65 days post-treatment (p.t.), although signs of damage were still observed, particularly in male worms, at 100 days p.t. In contrast, repair of damage to the subtegumental/parenchymal tissues including the tegumental perikarya occurred relatively quickly, with the majority of worms examined appearing normal by 8–12 days p.t. The possible role(s) of the host immune response in relation to the speed of tegumental repair in vivo is discussed.

Type
Research Article
Information
Parasitology , Volume 94 , Issue 2 , April 1987 , pp. 243 - 254
Copyright
Copyright © Cambridge University Press 1987

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