Hostname: page-component-586b7cd67f-t7fkt Total loading time: 0 Render date: 2024-11-24T15:22:59.779Z Has data issue: false hasContentIssue false
  • English
  • Français

Pathology of Angiostrongylus cantonensis infection in two model avian hosts

Published online by Cambridge University Press:  28 September 2020

Barbora Fecková Open the ORCID record for Barbora Fecková [Opens in a new window] ,
Priyanka Djoehana ,
Barbora Putnová ,
Michaela Valašťanová ,
Michaela Petríková ,
Zdeněk Knotek  and
David Modrý Open the ORCID record for David Modrý [Opens in a new window]
Barbora Fecková*
Affiliation:
Department of Pathology and Parasitology, University of Veterinary and Pharmaceutical Sciences, Palackého tř. 1946/1, Brno, Czech Republic
Priyanka Djoehana
Affiliation:
Department of Pathology and Parasitology, University of Veterinary and Pharmaceutical Sciences, Palackého tř. 1946/1, Brno, Czech Republic
Barbora Putnová
Affiliation:
Department of Pathology and Parasitology, University of Veterinary and Pharmaceutical Sciences, Palackého tř. 1946/1, Brno, Czech Republic
Michaela Valašťanová
Affiliation:
Department of Pathology and Parasitology, University of Veterinary and Pharmaceutical Sciences, Palackého tř. 1946/1, Brno, Czech Republic
Michaela Petríková
Affiliation:
Department of Pathology and Parasitology, University of Veterinary and Pharmaceutical Sciences, Palackého tř. 1946/1, Brno, Czech Republic
Zdeněk Knotek
Affiliation:
Department of Pathology and Parasitology, University of Veterinary and Pharmaceutical Sciences, Palackého tř. 1946/1, Brno, Czech Republic
David Modrý
Affiliation:
Department of Pathology and Parasitology, University of Veterinary and Pharmaceutical Sciences, Palackého tř. 1946/1, Brno, Czech Republic Institute of Parasitology, Biology Centre, Czech Academy of Sciences, České Budějovice, Czech Republic; Department of Botany and Zoology, Faculty of Science, Masaryk University, Brno, Czech Republic
*
Author for correspondence: Barbora Fecková, E-mail: [email protected]
Get access Rights & Permissions [Opens in a new window]

Abstract

Angiostrongylus cantonensis causes severe neurological disorders in a wide range of warm-blooded animals, including several avian species. A laboratory isolate of A. cantonensis originating from French Polynesia, genotyped as clade 2, was used to assess the effect of experimental infection in chicken and Japanese quail. Low dose groups of birds were infected orally by 100 L3 larvae, high dose groups by 1500 L3 larvae and the birds in the third group were fed three infected snails, mimicking a natural infection. Clinical signs during the first week after infection, haematology, biochemistry, gross lesions and histology findings were used to assess the pathology of the infection. Some of the infected birds showed peripheral eosinophilia, while mild neurological signs were seen in others. No larvae were observed in serial sections of the central nervous system of infected birds 1 week after infection and no major gross lesions were observed during necropsy; histopathology did not reveal lesions directly attributable to A. cantonensis infection. Our results suggest that galliform birds are not highly susceptible to A. cantonensis infection and open a question of the importance of Galliformes in endemic areas as natural pest control, lowering the number of hosts carrying the infective larvae.

Keywords

Angiostrongyluscantonensisexperimentalbirdchickenquail
Type
Research Article
Information
Parasitology , Volume 148 , Special Issue 2: 6th International Workshop on Angiostrongylus and Angiostrongyliasis, Hilo, Hawai'i, USA, January, 2020 , February 2021 , pp. 174 - 177
Check for updates
Copyright
Copyright © The Author(s) 2020. Published by Cambridge University Press

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Alicata, JE (1963) Incapability of vertebrates to serve as paratenic host for infective larvae of Angiostrongylus cantonensis. Journal of Parasitology 49, 48.Google Scholar
Ash, LR (1968) The occurrence of Angiostrongylus cantonensis in frogs of New Caledonia with observations on paratenic hosts of metastrongyles. The Journal of Parasitology 54, 432–436.CrossRefGoogle ScholarPubMed
Barnes, HJ and Fletcher, OJ (1996) Hemic system. In Barnes, H, Fletcher, OJ and Aziz, TA (eds). Avian Histopathology. American Association of Avian Pathologists, pp. 1–23.Google Scholar
Barratt, J, Chan, D, Sandaradura, I, Malik, R, Spielman, D, Lee, R, Mariott, D, Harkness, J, Ellis, J and Stark, D (2016) Angiostrongylus cantonensis: a review of its distribution, molecular biology and clinical significance as a human pathogen. Parasitology 143, 1087–1118.CrossRefGoogle ScholarPubMed
Beane, RD and Hobbs, NT (1983) The Baermann technique for estimating Protostrongylus Infection in bighorn sheep: effect of laboratory procedures. Journal of Wildlife Diseases 19, 7–9.CrossRefGoogle ScholarPubMed
Bhaibulaya, M (1975) Comparative studies on the life history of Angiostrongylus Mackerrasae Bhaibulaya, 1968 and Angiostrongylus cantonensis (Chen, 1935). International Journal for Parasitology 5, 7–20.CrossRefGoogle Scholar
Burns, RE, Bicknese, EJ, Qvarnstrom, Y, DeLeon-Carnes, M, Drew, CP, Gardiner, CH and Rideout, BA (2014) Cerebral Angiostrongylus cantonensis infection in a captive African pygmy falcon (Polihierax Semitorquatus) in southern California. Journal of Veterinary Diagnostic Investigation 26, 695–698.CrossRefGoogle Scholar
Červená, B, Modrý, D, Fecková, B, Hrazdilová, K, Foronda, P, Alonso, AM, Lee, R, Walker, J, Niebuhr, CN, Malik, R and Šlapeta, J (2019) Low diversity of Angiostrongylus cantonensis complete mitochondrial DNA sequences from Australia, Hawaii, French Polynesia and the Canary islands revealed using whole genome next-generation sequencing. Parasites and Vectors 12, 241.CrossRefGoogle ScholarPubMed
Cowie, RH (2013) Pathways for transmission of angiostrongyliasis and the risk of disease associated with them. Hawai'i Journal of Medicine & Public Health: a Journal of Asia Pacific Medicine & Public Health 72, 70–74.Google Scholar
Gelis, S, Spratt, DM and Raidal, SR (2011) Neuroangiostrongyliasis and other parasites in tawny frogmouths (Podargus strigoides) in south-eastern Queensland. Australian Veterinary Journal 89, 47–50.CrossRefGoogle Scholar
Gering, E, Johnsson, M, Willis, P, Getty, T and Wright, D (2015) Mixed ancestry and admixture in Kauai's feral chickens: invasion of domestic genes into ancient Red Junglefowl reservoirs. Molecular Ecology 24, 2112–2124.CrossRefGoogle ScholarPubMed
Graeff-Teixeira, C and Morera, P (1995) Metodo de digestao de moluscos em acido cloridrico para isolamento de larvas de metastrongilideos. Biociencias 3, 85–89.Google Scholar
Gregory, NG and Robins, JK (1998) A body condition scoring system for layer hens. New Zealand Journal of Agricultural Research 41, 555–559.CrossRefGoogle Scholar
Jindrak, K and Magnusson, MS (1981) Polymyositis and polyneuritis in experimental Angiostrongylus cantonensis infection of rabbits. Annals of Tropical Medicine and Parasitology 75, 205–210.CrossRefGoogle Scholar
Latimer, K and Bienzle, D (2010) Determination and interpretation of the avian leukogram. In Weiss, DJ and Wardrop, KJ (eds). Schalm's Veterinary Hematology. Ames, IA: John Wiley & Sons, pp. 345–357.Google Scholar
Li, H, Xu, F, Gu, JB and Chen, XG (2008) Case report: a severe eosinophilic meningoencephalitis caused by infection of Angiostrongylus cantonensis. American Journal of Tropical Medicine and Hygiene 79, 568–570.CrossRefGoogle ScholarPubMed
Lunn, J, Lee, R, Martin, P and Malik, R (2003) Antemortem diagnosis of canine neural angiostrongylosis using ELISA. Australian Veterinary Journal 81, 128–131.CrossRefGoogle ScholarPubMed
Lunn, JA, Lee, R, Smaller, J, MacKay, BM, King, T, Hunt, GB, Martin, P, Krockenberger, MB, Spielman, D and Malik, R (2012) Twenty two cases of canine neural angiostronglyosis in eastern Australia (2002-2005) and a review of the literature. Parasites and Vectors 5, 70.CrossRefGoogle Scholar
Ma, G, Dennis, M, Rose, K, Spratt, D and Spielman, D (2013) Tawny frogmouths and brushtail possums as sentinels for Angiostrongylus cantonensis, the rat lungworm. Veterinary Parasitology 192, 158–165.CrossRefGoogle ScholarPubMed
Mason, KV (1987) Canine neural angiostrongylosis: the clinical and therapeutic features of 55 natural cases. Australian veterinary journal 64, 201–203.CrossRefGoogle ScholarPubMed
Mason, KV (1989) Haematological and cerebrospinal fluid findings in canine neural angiostrongylosis. Australian Veterinary Journal 66, 152–154.CrossRefGoogle ScholarPubMed
Monks, DJ, Carlisle, MS, Carrigan, M, Rose, K, Spratt, D, Gallagher, A and Prociv, P (2005) Angiostrongylus cantonensis as a cause of cerebrospinal disease in a yellow-tailed black cockatoo (Calyptorhynchus funereus) and two Tawny Frogmouths (Podargus strigoides). Journal of Avian Medicine and Surgery 19, 289–293.CrossRefGoogle Scholar
Oliveira, APMM, Gentile, R, Maldonado Júnior, A, Lopes Torres, EJ, Thiengo, SC, Júnior, AM, Torres, EJL and Thiengo, SC (2015) Angiostrongylus cantonensis infection in molluscs in the municipality of São Gonçalo, a metropolitan area of Rio de Janeiro, Brazil: role of the invasive species Achatina Fulica in parasite transmission dynamics. Memorias do Instituto Oswaldo Cruz 110, 739–744.CrossRefGoogle Scholar
Qvarnstrom, Y, Bishop, HS and da Silva, AJ (2013) Detection of rat lungworm in intermediate, definitive, and paratenic hosts obtained from environmental sources. Hawai'i Journal of Medicine & Public Health: a Journal of Asia Pacific Medicine & Public Health 72, 63–69.Google ScholarPubMed
Reece, RL, Perry, RA and Spratt, DM (2013) Neuroangiostrongyliasis due to Angiostrongylus cantonensis in gang-gang cockatoos (Callocephalon fimbriatum). Australian Veterinary Journal 91, 477–481.CrossRefGoogle Scholar
Sawanyawisuth, K and Chotmongkol, V (2013) Eosinophilic meningitis. In Garcia, HH, Tanowitz, HB, O. H. D. B. (eds) Handbook of Clinical Neurology. Elsevier, pp. 207–215.Google Scholar
Tesana, S, Srisawangwong, T, Sithithaworn, P, Laha, T and Andrews, R (2009) Prevalence and intensity of infection with third stage larvae of Angiostrongylus cantonensis in mollusks from northeast Thailand. American Journal of Tropical Medicine and Hygiene 80, 983–987.CrossRefGoogle ScholarPubMed
Vitta, A, Polsut, W, Fukruksa, C, Yimthin, T, Thanwisai, A and Dekumyoy, P (2016) Levels of infection with the lungworm Angiostrongylus cantonensis in terrestrial snails from Thailand, with Cryptozona siamensis as a new intermediate host. Journal of Helminthology 90, 737–741.CrossRefGoogle ScholarPubMed
Walker, A, Spielman, D, Malik, R, Graham, K, Ralph, E, Linton, M and Ward, M (2015) Canine neural angiostrongylosis: a case-control study in Sydney dogs. Australian Veterinary Journal 93, 195–199.CrossRefGoogle ScholarPubMed
Wallace, GD and Rosen, L (1969) Studies on eosinophilic meningitis. V. Molluscan hosts of Angiostrongylus cantonensis on Pacific islands. The American journal of tropical medicine and hygiene 18, 206–216.CrossRefGoogle ScholarPubMed
Wang, QP, Lai, DH, Zhu, XQ, Chen, XG and Lun, ZR (2008) Human angiostrongyliasis. The Lancet Infectious Diseases 8, 621–630.CrossRefGoogle ScholarPubMed
Supplementary material: File

Fecková et al. supplementary material

Fecková et al. supplementary material 1

Download Fecková et al. supplementary material(File)
File 15.9 KB
Supplementary material: File

Fecková et al. supplementary material

Fecková et al. supplementary material 2

Download Fecková et al. supplementary material(File)
File 17.6 KB
Supplementary material: File

Fecková et al. supplementary material

Fecková et al. supplementary material 3

Download Fecková et al. supplementary material(File)
File 16.3 KB
Supplementary material: File

Fecková et al. supplementary material

Fecková et al. supplementary material 4

Download Fecková et al. supplementary material(File)
File 17.2 KB