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The Occurrence of Peculiar Bodies in Blood Cells of Animals after Treatment with some Chemical Compounds

Published online by Cambridge University Press:  06 April 2009

P. Tate  and
M. Vincent
P. Tate
Affiliation:
From the Molteno Institute for Research in Parasitology, University of Cambridge.
M. Vincent
Affiliation:
From the Molteno Institute for Research in Parasitology, University of Cambridge.
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Extract

Oral and subcutaneous administration of the compounds aminopropyl-aminostyrylmethoxyquinoline trihydrochloride and o-β-diethylaminoethyl harmol hydrochloride causes the appearance of peculiar bodies in the blood cells of canaries and mice.

The bodies are irregular in shape and size, stain intensely blue with Leish-man's and Giemsa's stains, and are most numerous in erythrocytes, but occur also in eosinophiles, leucocytes and reticulo-endothelial cells.

The bodies show no cytological structure, are not seen to undergo multiplication, and are not transmissible by blood inoculation.

They are apparently non-living inclusions in the blood cells caused by the action of these two chemical compounds.

Type
Research Article
Information
Parasitology , Volume 24 , Issue 2 , June 1932 , pp. 284 - 288
Copyright
Copyright © Cambridge University Press 1932

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References

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