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Neutrophils, apoptosis and phagocytic clearance: an innate sequence of cellular responses regulating intramacrophagic parasite infections

Published online by Cambridge University Press:  03 October 2006

F. L. RIBEIRO-GOMES ,
M. T. SILVA  and
G. A. DOSREIS
F. L. RIBEIRO-GOMES
Affiliation:
Instituto de Biofísica Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, 21949-900, Brazil
M. T. SILVA
Affiliation:
Institute for Molecular and Cell Biology, Porto, 4150-180, Portugal
G. A. DOSREIS
Affiliation:
Instituto de Biofísica Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, 21949-900, Brazil
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Abstract

In complex organisms, apoptosis is a constitutive cell death process that is involved in physiological regulation of cell numbers and that can also be induced in the course of inflammatory and immune responses. Neutrophils are among the first cells recruited during inflammation. Neutrophils constitutively die by apoptosis at inflamed sites, and are ingested by macrophages. Recent studies investigated how phagocytic clearance of senescent neutrophils influences the survival of intracellular protozoan parasites that have been phagocytosed by, or have invaded phagocytes. The results indicate that neutrophil clearance plays an unexpected role in regulation of intramacrophagic protozoan parasite infection.

Keywords

Leishmania majorneutrophilsapoptosismacrophagephagocytosis
Type
Research Article
Information
Parasitology , Volume 132 , Supplement S1: Programmed cell death and the protozoan parasite , March 2006 , pp. S61 - S68
Copyright
© 2006 Cambridge University Press

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