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Magnesium deficiency protects against Babesia hylomysci and mice become resistant to rechallenge with the parasite regardless of diet fed

Published online by Cambridge University Press:  06 April 2009

P. Maurois ,
P.H. Delcourt ,
E. Gueux  and
Y. Rayssiguier
P. Maurois
Affiliation:
INSERM U 42 (National Institute Health and Medical Research), 59650 Villeneuve d'Ascq, France and INRA (National Institute Agricultural Research), Human Nutrition Research Center, 63122 St-Genès-Champanelle, France
P.H. Delcourt
Affiliation:
INSERM U 42 (National Institute Health and Medical Research), 59650 Villeneuve d'Ascq, France and INRA (National Institute Agricultural Research), Human Nutrition Research Center, 63122 St-Genès-Champanelle, France
E. Gueux
Affiliation:
INSERM U 42 (National Institute Health and Medical Research), 59650 Villeneuve d'Ascq, France and INRA (National Institute Agricultural Research), Human Nutrition Research Center, 63122 St-Genès-Champanelle, France
Y. Rayssiguier
Affiliation:
INSERM U 42 (National Institute Health and Medical Research), 59650 Villeneuve d'Ascq, France and INRA (National Institute Agricultural Research), Human Nutrition Research Center, 63122 St-Genès-Champanelle, France
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Summary

Mice were fed diets containing 960 mg (control), 100 mg (moderately Mg deficient) and 30 mg (severely Mg deficient) of Mg/kg. After 20 days, mice were inoculated with Babesia hylomysci (from Dr Wery, Anvers, Belgium). Significant increases in RBC Mg levels were observed following infection. All the control and moderately deficient mice died from infection, whereas the severely Mg-deficient diet protected mice against infection, as shown by a decrease in parasitaemia and mortality. The decrease in RBC Mg, modifications in membrane properties and increased oxidant stress are possible explanations for the protective effect of severe Mg deficiency. When mice were maintained for 2 months after inoculation on a severely Mg-deficient diet and were then switched to a control diet, all survived and had low parasitaemias. After 1 month, these mice were rechallenged with B. hylomysci and 89% survived.

Keywords

Babesia hylomyscimagnesiumoxidative stressdiet
Type
Research Article
Information
Parasitology , Volume 108 , Issue 3 , April 1994 , pp. 245 - 248
Copyright
Copyright © Cambridge University Press 1994

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