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Is there reduced susceptibility to praziquantel in Schistosoma japonicum? Evidence from China

Published online by Cambridge University Press:  02 September 2010

WEI WANG ,
JIAN-RONG DAI ,
HONG-JUN LI ,
XUE-HUI SHEN  and
YOU-SHENG LIANG
WEI WANG
Affiliation:
Jiangsu Institute of Parasitic Diseases, Meiyuan, 117 Yangxiang, Wuxi 214064, Jiangsu Province, China
JIAN-RONG DAI
Affiliation:
Jiangsu Institute of Parasitic Diseases, Meiyuan, 117 Yangxiang, Wuxi 214064, Jiangsu Province, China
HONG-JUN LI
Affiliation:
Jiangsu Institute of Parasitic Diseases, Meiyuan, 117 Yangxiang, Wuxi 214064, Jiangsu Province, China
XUE-HUI SHEN
Affiliation:
Dantu District Center for Disease Control and Prevention, Dantu 212004, Zhenjiang City, Jiangsu Province, China
YOU-SHENG LIANG*
Affiliation:
Jiangsu Institute of Parasitic Diseases, Meiyuan, 117 Yangxiang, Wuxi 214064, Jiangsu Province, China
*
*Corresponding author: Jiangsu Institute of Parasitic Diseases, Meiyuan, 117 Yangxiang, Wuxi 214064, Jiangsu Province, China. Tel: +86 510 8551 7721. Fax: +86 510 8551 0263. E-mail: [email protected]
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Summary

Praziquantel is widely used for the treatment of human schistosomiasis. However, in recent years, there has been increasing concern about the resistance of Schistosoma species to praziquantel. The study described here was designed to evaluate the current susceptibility to praziquantel in S. japonicum in China. During the non-transmission period of schistosomiasis, a random sample of 4760 subjects from the main endemic foci of China were examined using parasitological stool examination. In total, 584 subjects were identified as being infected with S. japonicum, with a prevalence rate of 12 27%. Among them, 565 stool-egg-positive subjects were treated with praziquantel in a single oral dose of 40 mg/kg. Six weeks post-treatment, among the 505 villagers re-examined, 480 (95 05%) had no detectable S. japonicum eggs. Twenty-one subjects still excreting eggs after the first treatment were treated with praziquantel for the second time. All stool samples, including those from those participants with second treatment were re-examined 6 weeks after the second treatment, and no stool-egg-positives were found. The results indicate that the current efficacy of praziquantel against S. japonicum is still high and has not changed after more than 2 decades of repeated, expanded chemotherapy in the main endemic areas of China. It is suggested that no evidence of tolerance or resistance to praziquantel in S. japonicum was detected in China.

Keywords

Schistosoma japonicumpraziquantelsusceptibilitydrug resistancechemotherapyChina
Type
Research Article
Information
Parasitology , Volume 137 , Issue 13 , November 2010 , pp. 1905 - 1912
Copyright
Copyright © Cambridge University Press 2010

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