Introduction to neuropeptides: perspectives for the parasitologist

Extract

At the cellular and molecular levels, the small and simpler nervous systems of invertebrates do not differ fundamentally from the larger more complex ones of vertebrates. It seems therefore that the special properties of the human brain arise more from the fact that it has ten trillion cellular components than from any unusual properties of the components themselves. By studying invertebrates we can gain insight into what basic functions are performed by the cells and molecules of the nervous system and this will contribute to a more fundamental understanding of what goes on in a system in which the same functions are performed by uncountable numbers of neurones. Invertebrate studies are also important for an entirely different reason; they are interesting and important in their own right. Moreover, a relatively small number of invertebrates are pests; either parasites, vectors of serious parasitic diseases or pests of our agricultural production. It is no accident that most of the methods that are used to control such organisms act on their nervous system. That is because the nervous system is a complex chemical machine which works through a great variety of chemical interactions between a wide diversity of receptors and ligands. Many currently used control methods work because they disrupt these interactions. For this reason I would imagine that the new generation of compounds developed to control invertebrates will depend for their activity on interactions with the nervous system. Since most of the chemical effectors (transmitters, modulators and hormones) in the nervous system are peptides, a number of these newly developed approaches will depend upon a fundamental knowledge of peptidergic systems in parasites. This essay is about peptidergic systems and indicates how we might exploit their vulner-ability to interference.